摘要
角膜移植术后的免疫排斥反应是导致手术失败的主要原因之一,尤其在高危植床,排斥率可高达50%以上。糖皮质激素一直是目前防治免疫排斥反应的一线药物,局部应用是主要的用药途径,但长期应用需注意其眼部副作用;环孢霉素A滴眼液与糖皮质激素联合应用,可更好地预防免疫排斥反应发生,减少激素的副作用。他克莫司(FK506)局部应用也有良好效果。
Immune rejection after corneal penetrating keratoplasty is still one of the main reasons leading failure of the surgery, especially in hlgh-risk cases, in whom the rejection ratio can be as high as 50%. Glucocorticoid is still the first-line drug for the pre- vention and treatment of corneal graft rejection, and topical application of which is the main way of administration, but long-term using of which should be paid more attention to avoiding the side effects. Cyclosporin A （CsA） eye drops in combination with glucocorticoid can be better to prevent immune rejection episodes and reduce the side effects of steroid. Topical tacrolimus application also showes a good result.
出处
《眼科》
CAS
2013年第3期145-146,共2页
Ophthalmology in China
关键词
角膜移植
免疫排斥
免疫抑制剂
corneal transplantation
immune rejection
immunosuppressant
