摘要
目的:探讨高危型人乳头瘤病毒及甾体类激素受体ER、PR在宫颈癌及癌前病变中的表达及临床病理意义。方法:采用原位杂交及免疫组织化学染色方法检测HPV、ER、PR在不同程度的宫颈病变组织中的表达情况。结果:HPV16/18在正常宫颈组织表达率为0,随着病变严重程度的增加,HPV16/18的表达率逐渐升高,至高度上皮内瘤变组(CINII、III级)达高峰。HPV16/18在各组间的表达差异具有显著统计学意义(P<0.01)。HPV31/33主要在低度上皮内瘤变组中表达。ER、PR的表达率及表达强度随着病变程度的增加逐渐降低,各组间的差异具有显著的统计学意义(P<0.01)。结论:HR-HPV感染是诱发宫颈癌的首要启动因素,ER、PR在HPV感染引起的宫颈癌早期起促进作用,但PR也可能起抑制作用。
Objective:To explore the expression of HR-HPV and ER,PR in cervical cancer tissues with different degree of severity and its clinicopathologic significance.Methods:Immunihistochemistry and in situ hybridisation were used to detect the expression of HR-HPV and ER,PR in normal cervical tissues,cervical intraepithelial neoplasm(CIN) and cervical cancers.Results:The positive rate of HPV16/18 was 0 in the normal cervical tissue,its positive rate and staining intensity increased with the severity of the disease arrived at peak at high intraepithelial neoplasia(CIN II,III).There was significant difference(P0.01)between different groups.HPV31/33 was detected dominantly in group CIN I.The staining intensity and positive rate of ER,PR were significant different(P0.01)between different groups.Conclusion:HR-HPV may play an principal start role in the pathogenesis of cervical cancer.ER,PR serve as promoting effect in early cervical cancer caused by HPV,but PR may has an inhibitory effect.
出处
《现代肿瘤医学》
CAS
2013年第7期1571-1574,共4页
Journal of Modern Oncology
基金
北京市海淀区科技项目(编号:K2008058)