p57^(kip2)、LIMK1与宫颈癌淋巴结转移的关系

The relationship of p57^(kip2) and LIMK1 with lymphatic metastasis of cervical cancer

目的:检测细胞周期抑制因子p57kip2和细胞骨架蛋白LIMK1在宫颈癌中的表达水平,探讨两者在宫颈癌发生发展中的作用。方法:用免疫组织化学方法检测37例宫颈癌组织和37例宫颈癌旁组织中p57kip2和LIMK1的表达水平;分析p57kip2和LIMK1与宫颈癌临床病理因素的关系及两者间的关系。结果:p57kip2在宫颈癌组织中的阳性率29.7%,显著低于癌旁宫颈组织(86.5%)(P<0.05),p57kip2的缺失表达与进展期宫颈癌(Ⅲ期+Ⅳ期)和淋巴结转移有关(P<0.05)。LIMK1在宫颈癌组织中的阳性率40.5%,显著低于癌旁宫颈组织(75.7%)(P<0.05),LIMK1的低表达与淋巴结转移有关(P<0.05)。且p57kip2和LIMK1的表达呈正相关(P<0.05)。结论:p57kip2和LIMK1的异常表达可能参与了宫颈癌的发生发展,两者可能协同调控宫颈癌的淋巴结转移。

Objective：To evaluate the expression level of p57kip2 and LIMK1 in cervical carcinoma,to explore the role of p57kip2 and LIMK1 in the genesis and progression of cervical carcinoma.Methods：We evaluated p57kip2 and LIMK1 by immunohistochemistry in 37 cervical carcinoma tissues and compared to 37 adjacent non-cancerous tissues.The mutual relationships for clinicopathologic factor and p57kip2 as well as LIMK1 were analysed.Results：The expression of p57kip2 in cervical carcinoma（29.7%）was significantly lower than that in adjacent non-cancerous tissues（86.5%）（P0.05）.The absence of p57kip2 was associated with advanced cervical carcinoma（Ⅲ＋Ⅳ stage）and lymphatic metastasis（P0.05）.The expression of LIMK1（40.5%）decreased in cervical carcinoma compared to adjacent non-cancerous tissues（75.7%）（P0.05）.The absence of LIMK1 was associated with lymphatic metastasis of cervical carcinoma（P0.05）.Moreover,the positive correlation between p57kip2 and LIMK1 was observed in cervical carcinoma tissues（P0.05）.Conclusion：The abnormal expression of p57kip2 and LIMK1 might participate in the occurrence and progression of cervical carcinoma,and coordinately regulate lymphatic metastasis of cervical cancer.