期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

FANCF基因与肿瘤发生和耐药性形成的研究进展 被引量：1

Research progress on tumorigenesis and resistance with FANCF
下载PDF
导出
摘要 范可尼贫血(Fanconi anemia,FA)是一种罕见的常染色体遗传病。FA复合体可通过FA/BRCA通路参与细胞周期调控、细胞凋亡、DNA修复等生命信号转导与调控。范可尼贫血相关基因F(Fanconi anemia complementation group F,FANCF)作为关键因子,参与FA复合体稳定、FANCD2泛素化及FA/BRCA通路生物学功能调控。研究表明,FANCF在肿瘤的发生和耐药性形成发挥重要作用。本文对该方面的相关研究进行综述。 Tumor stem cell is a new hot point in the research of tumor.Tumor stem cell marker is the window to tumor stem cell research.At present,non small cell lung cancer stem cell marker has no clear conclusion.This paper summarizes the present study of non small cell lung cancer stem cell marker,to provide reference for the further related studies.
作者 王俊 赵琳 何苗 魏敏杰
机构地区 中国医科大学 中国医科大学药学院药理教研室
出处 《现代肿瘤医学》 CAS 2013年第7期1629-1632,共4页 Journal of Modern Oncology
基金 国家自然科学基金(编号:30873097 编号:81173092 编号:81202551) 辽宁省科学技术计划项目(编号:201141 5052)
关键词 FANCF FA BRCA通路 肿瘤 耐药 FANCF FA/BRCA pathway tumor resistance
分类号 R730.231 [医药卫生—肿瘤]
  • 相关文献

参考文献38

  • 1Meetei AR, Levitus M, Xue Y, et al. X -linked inheritance of Fan- eoni anemia complementation group B [ J ]. Nat Genet, 2004,36 : 1219 - 1224.
  • 2Leveille F, Blom E, Medhurst AL, et al. The fanconi anemia gene product FANCF is a flexible adaptor protein [ J ]. Biol Chem,2004, 279 ( 38 ) : 39421 - 39430.
  • 3D 'Andrea AD. Susceptibility pathways in Fanconi 's anemia and breast cancer[J]. N Engl J Med,2010,362(20) :1909 -1919.
  • 4Stoepker C, Hain K, Schuster B, et al. SLX4, a coordinator of struc- ture -specific endonucleases, is mutated in a new Fanconi anemia subtype[ J]. Nat Genet,2011,43 (2) : 138 - 141.
  • 5Vaz F, Hanenberg H, Schuster B, et al. Mutation of the RAD51C gene in a Fanconi anemia- like disorder[ J]. Nat Genet,2010,42 (5) :406 -409.
  • 6Vuorela M, Pylkas K, Hartikainen JM, et al. Further evidence for the contribution of the RAD51 C gene in hereditary breast and ovar- ian cancer susceptibility [ J ]. Breast Cancer Res Treat, 2011,130 (3) :1003 - 1010.
  • 7Foe JR, Rooimans MA, Bosnoyan - Collins L, et al. Expression clo- ning of a cDNA for the major Fanconi anaemia gene,FAA[ J]. Nat Genet,1996,14(4) :320-323.
  • 8Ferrer M, Rodriguez JA, Spierings EA, et al. Identification of multi- ple nuclear export sequences in Fanconi anemia group A protein that contribute to CRM1 -dependent nuclear export[ J]. Hum Mol Genet,2005 ,14(10) :1271 - 1281.
  • 9Yamashita T, Barber DL, Zhu Y, et al. The Fanconi anemia poly- peptide FACC is localized to the cytoplasm [ J ]. Proc Natl Acad Sci USA,1994,91 (14) :6712 -6716.
  • 10De Winter JP,Leveille F,van Berkel CG,et al. Isolation of a cD- NA representing the Fanconi anemia complementation group E gene [ J]. Am J Hum Genet,2000,67 (5) :1306 - 1308.

二级参考文献50

  • 1JOENJE H, PATEL KJ. The emerging genetic and molecular basis of Fanconi anaemia [ J ]. Nat Rev Genet, 2001,2(6) : 446-457.
  • 2LEVITUS M,ROOIMANS MA,STELTENPOOLJ,et al. Heterogeneity in Fanconi anemia:evidence for 2 new genetic subtypes [J]. Blood, 2003,103(7) :2498-2503.
  • 3MEETEI AR,DE WINTER JP,MEDHURST AL,et al. A novel ubiquitin ligase is deficient in Fanconi anemia [J ]. Nat Genet, 2003,35 (2) : 165-170.
  • 4DE WINTER JP,VAN DER WEEI L,DE GROOT J,et al. The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCCand FANCG [ J ] .Hum Mol Genet, 2000,9( 18 ) : 2665-2674.
  • 5MEDHURST AL,HUBER PA,WAISFISZ Q,et al. Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway [ J ]. Hum Mol Genet, 2001,10(4 ) : 423-429.
  • 6FRANCE L,ERIC B ,ANNETFE LM,et al. The Fanconi anemia gene product fancfis a flexible adaptor proteinp [J]. J Biol. Chem,2004,279 (38) : 39421-39430.
  • 7BUTTURINI A, GALE RP, VALANDER PC, et al. Hematologic abnormalities in Fanconi anemia : an international Fanconi anemia registry study [J]. Blood, 1994,84(5) : 1650-1655.
  • 8ZELLER C, BROWN R. Therapeutic modulation of epigenetic drivers of drug resistance in ovarian cancer[J]. Ther Adv Med Oncol, 2010, 2(5): 319-329.
  • 9SWISHER E M, GONZALEZ R M, TANIGUCHI T, et al. Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas[J]. Mol Cancer, 2009, 8: 48.
  • 10LIM S L, SMITH P, SYED N, et al. Promoter hypermethylation of FANCF and outcome in advanced ovarian cancer[J]. BrJ Cancer, 2008,98(8): 1452-1456.

共引文献12

同被引文献8

引证文献1

现代肿瘤医学
2013年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部