早期糖尿病视网膜病变与视觉诱发电位相关研究

P-VEP manifestation in early non-proliferative diabetic retinopathy

目的分析图形视觉诱发电位(P-VEP)与早期糖尿病视网膜病变(DR)之间的关系,研究P-VEP对早期DR的诊断作用。方法对30例(60只眼)正常人和80例(160只眼)糖尿病患者进行P-VEP检测。结果DR患者眼底尚未出现改变时,P-VEP的LP100、AP100差异有统计学意义,但与DR进展无明显相关性。结论 P-VEP的相关参数能够在眼底尚未出现明显病变之前预测DR的发生,但与DR的发展无显著相关性,在DR的早期诊断有一定的临床应用价值。

Objective The aim of this study is to investigate the risk factors of diabetic retinopathy （DR） to examine the relationship between VEP and the onset of early DR. Methods In this study, patients with early DR are elassifled into four Stoups accovrling to sub-stages of eady DR, i. e, DR-0 stage, mild, moderate and severe non-proliferatve dl- abetlc retinopathy （ NPDR ）. P-VEP examinations were performed in each group （ n = 20 ） and in 30 normal subjects for control. Results Compared with controlled group, the level of LPI00 in DR-0, mild NPDR, moderate NPDR and severe NPDR is 109.2,28.7, 104.8 ±32.9, 112.4 ±38.7, and 106.5 ±39.6, respectively. It was not correlated with the se- verity of NPDR （ r =0. 147）. AP100 was 11.6 ±4.51, 12. 1 ±3.79, 11.3 ±5.26, and 10.9 ±6.21, respectively, and was not correlmed with the severity OfNPDR （ r =0.214） either. Conclusion TheLP100 and AP100 are both Hsher in NPDR patients, which is helpful to the early diagnosis. However, LP100 or AP100 is not eoneJated with the severity of NPDR.