成分输血治疗重度子痫前期的实验性疗效分析

Therapeutic Efficacy of Blood Component Transfusion in the Treatment of Severe Preeclampsia

目的通过测定重度子痫前期患者输血治疗前后止凝血分子标志物凝血酶原片断1+2(F1+2)、凝血酶调节蛋白(TM)的变化,观察成分输血治疗重度子痫前期的疗效。方法选择40例重度子痫前期患者,给予预防性成分输血治疗,分析输血治疗前后止凝血分子标志物F1+2,TM的变化及临床症状情况的改善,并统计终止妊娠前后的用血量。结果重度子痫前期患者成分输血治疗后F1+2,TM等反应高凝状态指标与输血前比较均明显改善,差异有统计学意义(P<0.01或P<0.05)。结论①正常妊娠妇女随孕周增加F1+2及TM呈增加趋势,但重度子痫前期患者增加更显著,动态监测重度子痫前期患者体内血浆F1+2及TM水平升高的情况可了解病情的进展程度及严重程度。②成分输血预防性输注治疗能明显改善重度子痫前期患者体内的慢性DIC状态的凝血机制。

Objective To explore effectiveness of component transfusion in cure severe preeclampsia（PE） ,by monitoring the changes of prothrombin fragment 1 ＋ 2 （ F1 ＋ 2 ） and thrombomodnlin （ TM ） in severe preeclampsia from blood transfusion before and alter. Methods Forty severe PE patients were treated by component blood transfusion,analysed the change of F1 ＋ 2 and TM,observed status of clinical symptoms,and counted up the blood volume before and after the termination of pregnancy. Results The level of F1 ＋ 2 and TM in severe preeclampsia had significant difference（ P 〈 0.01 ,P 〈 0.05 ） before and after component blood transfusion treatment. Conclusions ①The value of H ＋ 2 and TM is rising as pregnancy advanced in the normal pregnancy women, but have more significantly increase in the se- vere PE patients. Dynamic monitoring the levels of TM and F1 ＋ 2 in severe preeclampsia can reflect the process of the disease development and the order of severity. ②The hemoglutination mechanism of DIC condition in PE can be obviously improved through component blood transfusion treatment.