神经外科手术后颅内感染早期脑脊液中IL-6、IL-8和TNF-!水平变化的意义

Clinical Significance of Interleukin-6,Interleukin-8 and Tumor Necrosis Factor Alpha in Cerebrospinal Fluid of Patients with Intracranial Infection After Neurosurgery Operation

目的通过研究神经外科手术后颅内感染患者脑脊液中的IL-6、IL-8和TNF-α的水平变化,探讨其在术后颅内感染中的诊断价值。方法选取我院神经外科手术后颅内感染患者46例,非颅内感染患者34例,所有病例均于手术后1～7天内和7～14天取脑脊液进行IL-6、IL-8和TNF-α的检测,并进行统计分析。结果神经外科手术后颅内感染组患者1～7天内的脑脊液中IL-6、IL-8和TNF-α的含量显著高于非感染组患者,差异有统计学意义(P<0.05);颅内感染患者7～14天的脑脊液中IL-6、IL-8和TNF-a的含量虽高于非感染组患者,但差异没有统计学意义(P>0.05)。结论结合临床症状和有效的检查脑脊液中IL-6、IL-8和TNF-α水平,可明显提高神经外科术后颅内感染早期的诊断价值和准确性,值得临床推广。

Objective To investigate the level of IL-6,IL-8 and TNF-α in cerebrospinal fluid of patients with intracranial infection after neurosurgery operation and its diagnostic value.Methods The CSF concentrations of IL-6,IL-8 and TNF-α were determined in 46 cases of patients with intracranial infection and 34 patients with non-intracranial infection during 1-7 days and 7-14 days after neurosurgery operation.Results The CSF concentrations of IL-6,IL-8 and TNF-α in patients with intracranial infection were obviously higher than that in patients with non-intracranial infection during 1-7days and 7-14 days after neurosurgery operation,especially in 1-7 days.There was statistical difference of IL-6,IL-8 and TNF-α level between intracranial infection group and the control group in 1-7days.Conclusion Combined with clinical symptoms,the detection of IL-6,IL-8 and TNF-α may be served to prove the diagnostic value and accuracy in patients with intracranial infection after neurosurgery operation.