浙江省1997至1999年肾综合征出血热监测分析

Surveillance and Analysis of HFRS in Zhejiang Province

目的 :通过监测分析 ,掌握全省肾综合征出血热 (HFRS)流行规律 ,控制暴发流行 ,进一步降低发病率 ,制订防制措施。方法 :采用直接免疫荧光法 (FAT)检测鼠肺HV抗原 ;采用间接免疫荧光法 (IFAT)检测HFRS病人、健康人血清以及鼠血中HV抗体。结果 :1997～ 1999年全省共发病 75 34例 ,年均发病率为 5 .6 5 / 10万 ,死亡 39人 ,病死率为 0 .5 2 %。病例仍主要分布在沿钱塘江两岸的浙东和浙西丘陵区 ,浙南山区次之 ,浙北平原区和海岛区病例较少 ;全省 11个地市 (除舟山以外 )均有发病 ,以浙东和浙西丘陵区的绍兴、宁波、台州、衢州、杭州和金华 6市发病最多 ,占全省病例总数的 87.44 %。宿主动物野外以黑线姬鼠为优势种 ,占 80 .2 4% ;室内以褐家鼠为优势种 ,占 85 .0 0 %。结论 :进一步加大监测力度及接种HFRS疫苗 。

Purpose:Grasp HFRS's prevalent regularity in whole province, control its outbreak and work out the way to deal with it. Method: Use Direct Fluorescent Antibody Technic (DFAT) to test HV antigen in rat's lung, use Indirect Fluorescent Antibody Technic (IFAT) to test HV antibody in serum of patient and people in good health. Result: There were 7 534 patients in whole province from 1997 to 1999, and 39 of them died. The average morbidity was 5.65 per 100 000 persons. Most patients were in the east and west hilly land of Zhejiang province. 11 cities of Zhejiang province all had patients. The patients were both disperse and relatively concentrately. 87.44 percent of patient came from Shaoxing、Ningbo、Taizhou、Xuzhou、Hangzhou and Jinhua city. Most HFRS'S host animal in field was Apodemus agrarius Pallas, most host animal in the house was Rattus norvegicus Berkenhout. Conclusion: We must enhance HFRS's surveillance and vaccinate people with HFRS's vaccine.