在女性冠心病患者测定幽门螺杆菌的意义

Significance detecting Helicobacter pylori in female patients with coronary heart disease

目的:探讨在女性冠心病患者治疗过程中检测幽门螺杆菌(HP)的临床意义。方法:188例冠心病患者均进行14 C试验,根据检测结果分为HP阳性组(84例)和HP阴性组(104例),各组按照性别又分为男性和女性两个亚组,每组患者均接受冠心病的标准治疗方案,分别观察患者消化道出血发生的情况。结果:1个月内,阳性组的女性消化道出血发生率明显高于男性(19.4%比4.17%,χ=5.02,P<0.05);阴性组男女消化道出血发生率无显著差异(χ=0.04,P>0.05)。讨论:幽门螺杆菌测定对于冠心病女性患者的临床治疗药物的选择有指导作用,应尽早对于HP阳性患者采取消除HP治疗,减少胃肠道出血率。

Objective：To explore clinical significance detecting Helicobacter pylori（HP）during treatment of female patients with coronary heart disease（CHD）.Methods：A total of 188CHD cases all received14 C test.According to test result,they were divided into HP positive group（n=84）and HP negative group（n=104）.And these two groups were further divided into male and female subgroups.All patients received standard treatment of CHD,and incidence of gastrointestinal bleeding was observed in each group.Results：Compared with male subgroup,there was significant increase in incidence rate of gastrointestinal bleeding within one month（4.17%vs.19.4%,χ=5.02,P〈0.05）in female subgroup of positive group;there was no significant difference in incidence rate of gastrointestinal bleeding between male and female subgroup in negative group（χ=0.04,P〈0.05）.Conclusion：Detection of Helicobacter pylori can guide clinical medication choice in patients with coronary heart disease.It suggests that should take treatment for revoke Helicobacter pylori to decrease gastrointestinal bleeding.