多烯磷酯酰胆碱预防抗结核药对老年患者肝损害作用

The effect of polyene phosphatide acyl choline in prevent the elderly patients liver lesion caused by antituberculotic drugs

目的探讨多烯磷脂酰胆碱在老年肺结核患者中预防抗结核药物的肝功能损害的作用。方法选取老年肺结核患者80例,随机分为治疗组和对照组,各40例,均用异烟肼、利福平、吡嗪酰胺、乙胺丁醇四联强化抗结核方案治疗,治疗组加用多烯磷脂酰胆碱胶囊456 mg,po,tid。共观察8周。结果治疗组累计肝功能损害发生5例,对照组累计肝功能损害发生12例(P<0.05),在有肝功能损害的患者中,对照组ALT升高明显,与治疗组比较差异有统计学意义(P<0.05),对照组TBIL升高,治疗组无明显升高。结论多烯磷脂酰胆碱可以预防老年肺结核患者抗结核药所致肝损害的发生,减轻肝损害程度,而且安全可靠,值得临床推广应用。

Objective To discuss the effect of polyene phosphatide acyl choline in prevent the elderly patients liver lesion caused by antituberculotic drugs.Methods 80 cases of elderly tuberculosis patients were selected,80 cases were randomly divided into the treatment group and control group 40 cases each,The treatment of anti-TB were oral isoniazid,rifampicin,pyrazinamide and ethambutol.The treatment group was added with polyene phosphatidylcholine capsules,456 mg Po,dar,for 8 weeks.Results Treatment group total liver lesion in 5 cases,control group total liver lesion in 12 cases（P0.05）,in patients with liver lesion,the control group ALT increased significantly,there was significant difference between the treated groups and the control groups（P0.05）,the control group ALT increased,while the treatment group has no obvious rise.Conclusion Polyene phosphatidyl choline can prevent senile pulmonary tuberculosis in patients with liver lesion induced by anti-tuberculosis drugs,reducing the level of liver lesion,and safety and reliable,and worthy to be clinically popularized and applied.