黄术消肿洗剂多次给药对家兔皮肤刺激性实验

Study on Irritation of Rabbit Skin Caused by Multi-dose Huangzhu Xiaozhong Lotion

目的探讨黄术消肿洗剂对家兔皮肤的刺激性,为临床安全用药提供安全性依据。方法对健康大耳白家兔进行急性皮肤刺激、破损皮肤刺激及多次皮肤刺激实验,观察黄术消肿洗剂对家兔完整和破损皮肤的刺激性。结果黄术消肿洗剂对家兔完整皮肤和破损皮肤未见刺激性。结论黄术消肿洗剂对家兔皮肤无明显刺激作用,临床应用安全可靠。

Objective To probe into irritation of rabbit skin induced by Huangzhu Xiaozhong Lotion so that evidence could be provided for clinical application of Huangzhu Xiaozhong Lotion. Methods Acute skin irritation,scraped skin irritation and dermal sensitiviW test were performed on the healthy rabbits in order to observe the irritation on complete and scraped skin of rabbit. Results Huangzhu Xiaozhong Lotion showed no irritation to complete and scraped skin of rabbit. Conclusion Huangzhu Xiaozhong Lotion demonstrated no skin toxic reaction to rabbit and could be widely used in clinic.