膝关节创伤后炎性细胞因子变化的研究现状

Advance in Inflammatory Cytokines in Post-traumatic Knee (review)

膝关节创伤后周围组织,包括关节囊、滑膜、关节软骨、半月板等,均能产生炎症介质,这就提示膝关节创伤后疼痛及僵直与其局部的炎症反应及炎性细胞因子有关。这些炎性细胞因子中有促进和加速炎症反应的因子如肿瘤坏死因子、白细胞介素-1、白细胞介素-2、白细胞介素-6、环氧酶等。本文介绍膝关节创伤后周围组织部分炎性细胞因子的研究现状,分析目前研究存在的不足,为进一步研究奠定基础。

Tissues around the post-traumatic knee, including the capsule, synovial, articular cartilage, meniscus, etc., can produce in- flammatory mediators. This suggested that post-traumatic knee pain and stiffness are related with local inflammation and inflammatory cyto- kines. These inflammatory cytokines included the inflammatory response factor of advancement and acceleration, such as tumor necrosis factor, interleukin-1, interleukin-2, interleukin-6, cyclooxygenase, etc. This article reviewed the researches about some inflammatory cyto- kines surrounding tissue of post-traumatic knee, analyzed current research shortcomings, and established the foundation for further study.