重复经颅磁刺激对失眠症患者睡眠参数的影响

Effects of Transcranial Magnetic Stimulation on Polysomnography in Patients with Insomnia

目的观察经颅磁刺激治疗仪治疗失眠症患者的临床疗效。方法选择20例健康者作为正常组,将60例睡眠障碍患者分为安定药物组和经颅磁刺激组,各30例。安定药物组采用常规药物治疗,每晚口服安定5 mg,经颅磁刺激组行经颅磁刺激治疗,均治疗14 d,经多导睡眠检测仪检测治疗前后两组患者睡眠进程和睡眠结构的变化。正常组不接受任何治疗,仅在选中入组时做1次多导睡眠监测,比较两组疗效。结果治疗后两组患者的睡眠时间、睡眠潜伏期、觉醒时间、睡眠效率等较治疗前均改善(P<0.05),治疗后经颅磁刺激组与安定药物组相比,深睡眠时间增加,睡眠结构趋于正常。结论经颅磁刺激治疗仪治疗睡眠障碍有明显疗效。

Objective To explore the effect of transcranial magnetic stimulation （TMS） on polysomnography in patients with insomnia. Methods 20 healthy volunteers and 60 patients with primary insomnia from the outpatient department were chosen. The insomnia patients were divided into 2 groups with 30 patients in each group, one group received TMS every day, the other group received benzodiazepine 5 mg every night, both groups were treated for 14 days. The healthy volunteer received no treatment. The effect was assessed with polysom- nography before and after treatment. 20 healthy voltmteers were as the normal group and they were assessed by polysomnography only when they were collected. Results TMS and benzodiazepine have the same effect on sleep latency, sleep time, awakening time and sleep effi- ciency. And TMS may increase S3-S4 and rapid eye movement sleep. Conclusion TMS has better effect than benzodiazepine in the treatment of sleep disorder.