多巴丝肼对脑卒中患者患侧上肢功能的影响

Effects of Levodopa and Benserazide on Upper Extremity Function after Stroke

目的观察多巴丝肼对脑卒中偏瘫患者上肢功能恢复的影响。方法 90例脑卒中偏瘫患者,采用随机数字表法将其分为康复组、治疗组及对照组,每组30例。前两组患者均给予运动疗法治疗,其中治疗组患者加用口服多巴丝肼治疗。分别于治疗前、治疗8周时采用Fugl-Meyer评分法(FMA)、运动功能评估量表(MAS)对患者上肢功能进行评定。结果治疗前,三组患者上肢FMA及MAS评分无显著性差异(P>0.05);治疗8周后,前两组患者上肢FMA及MAS评分均较治疗前改善(P<0.05),治疗组较康复组改善,且均优于对照组(P<0.05)。结论多巴丝肼可进一步改善患侧上肢运动功能。

Objective To explore the effects of levodopa and benserazide on upper extremity function after stroke. Methods 90 cases of sub-acute stroke patients were randomly divided into rehabilitation group （n=30）, treatment group （n=30） and control group （n=30）. The first 2 groups were treated with conventional movement therapy. The treatment group was treated with levodopa and benserazide tablet in addi- tion. All patients were assessed with Fugl-Meyer assessment （FMA） and Motor Assessment Scale （MAS） before and 8 weeks after treat- ment. Results Before treatment, there was no significant difference in the scores of FMA and MAS among 3 groups （P〉0.05）. After 8 weeks treatment, the scores of FMA and MAS increased in the rehabilitation group and treatment group （P〈0.05）, the score was higher in the treat- ment group than in the rehabilitation group （P〈0.05）. Conclusion Levodopa and benserazide can further improve the functional performance of the upper extremities of stroke patients.