住院方式对慢性精神分裂症患者生活质量的影响

Influence of Admission Mode on Quality of Life of Patients with Chronic Schizophrenia

目的比较分析不同住院方式对慢性精神分裂症患者生活质量的影响。方法将200例慢性精神分裂症患者随机分为间断组和连续组,每组100例。两组均使用非典型抗精神病药,间断组采取间断住院结合家庭治疗模式,连续组采取连续住院模式,观察治疗1年。用阳性和阴性综合征量表(PANSS)和精神分裂症生活质量量表(SQLS)分别评定患者干预前、干预6个月和1年时病情和生活质量的变化。结果两组的干预方法对PANSS和SQLS评分有随时间变化的趋势,入组后6个月末和1年末评分较入组时显著下降(F组内=2119.531,390.981,均P=0.000);干预与时间存在交互效应(F交互=17.660,11.709,均P=0.000);PANSS评分存在组间差别(F组间=19.673,P=0.000);间断组减分幅度显著大于连续组(P=0.000)。结论间断住院结合家庭治疗较连续住院模式更有利于患者病情控制和生活质量的改善和保持。

Objective To compare the influence of different admission modes on quality of life of patients with chronic schizophrenia. Methods 200 patients with chronic schizophrenia were randomly assigned to discontinuous group and continuous group with 100 cases in each group. All patients were treated with atypical antipsychotic drugs. A discontinuous hospitalization combined with home treatment was given to the discontinuous group and a continuous hospitalization to the continuous group for 1 year. The Positive and Negative Syndrome Scale （PANSS） and the Schizophrenia Quality of Life Scale （SQLS） were respectively used to evaluate the patient＇s condition and quality of life before and after the intervention. Results The intervention methods on scores of PANSS and SQLS in both groups had a change trend with time. The scores of PANSS and SQLS were significantly lower in the end of 6 months and 1 year after intervention than before in both groups （F=21 l 9.513, 390.981, P=0.000）. There was a interaction effect between intervention method and time in both groups on the scores of PANSS and SQLS （F=17.660, 11.709, P=0.000）. There was significant difference between 2 groups on the score of PANSS （F=19.673, P=0.000）. The decrease range of those scores was greater in the discontinuous group than in the continuous group （P=0.000）. Conclusion A discontinuous hospitalization combined with home treatment is more beneficial than a continuous hospitalization for the patients with chron- ic schizophrenia in controlling the syndrome and improving or keeping the quality of life.