间接胆红素在血浆置换联合山莨菪碱治疗血栓性血小板减少性紫癜中的变化观察

The observation the change of indirect bilirubin on plasma exchange combined with anisodamine in treatment of thrombotic thrombocytopenic purpura

目的观察间接胆红素(I-Bil)在山莨菪碱加血浆置换(PE)干预血栓性血小板减少性紫癜(TTP)的变化情况,以了解山莨菪碱在TTP干预中的效果。方法选择82例TTP患者随机分组,联合干预组41例予山莨菪碱加血浆置换(PE),疗程21d;对照组41例单纯予以PE干预,疗程21d。结果联合干预组21d后有效率90.2%,对照组有效率82.9%,差异有显著性(P<0.05),I-Bil在干预后第2、5、12d数值下降速度明显快于对照组,差异有显著性(P<0.05),有统计学意义。结论血浆置换联合山莨菪碱注射液干预血栓性血小板减少性紫癜间接胆红素下降更快,疗效更好。

Objective To investigate the clinic efficacy and the change of indirect bilirubin on plasma exchange（PE） combined with anisodamine in the treatment of thrombotic thrombocytopenic purpura（TTP）.Methods 82 patients were randomized into two groups,each group contained 41patients,the treatment group is given anisodamine injection combined with plasma exchange（PE）,and the period of treatment is 21 days;the controlled group is just given plasma exchange and the period is also 21 days.Results The efficacy of the combined treatment group for 21 days is 90.2%,the controlled group is 82.9%,there were significant difference between tow groups（P0.05）.The indirect bilirubin descend faster after treatment for 2,5 and 12 days than the controlled group,there were significant difference（P0.05）,and there is statistic meaning.Conclusion Anisodamine combined with plasma exchange shows better clinic effect and the indirect bilirubin descend faster than plasma exchange alone in therapy of thrombotic thrombocytopenic purpura.