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缺氧诱导因子-1α在膀胱癌中的表达及意义 被引量：1

Expression and significance of hypoxia-inducible factor-1 α in bladder cancer
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摘要 目的探讨缺氧诱导因子-1α(HIF-1α)在膀胱癌组织中的表达及其意义。方法采用免疫组织化学技术对30例新鲜的膀胱癌患者的肿瘤组织和15例正常膀胱组织检测HIF-1α的表达情况,比较两组之间的差异。结果 30例膀胱癌组织中23例(76.7%)呈阳性表达,而15例正常膀胱组织中仅1例阳性表达,差异有统计学意义(P<0.05)。结论 HIF-1α蛋白的高表达可能与膀胱癌的发生、发展和复发有关。 Objective To discuss expression and significance of hypoxia-inducible factor-1 α（HIF-1α） in bladder cancer.Methods Fresh tissues of 30 cases of bladder cancer and tissues of 15 cases of normal bladder were treated with immunohistochemistry to detect expression of HIF-1α.Difference was compared.Results 23 cases of bladder cancer was positive（76.7%） and 1 case of normal bladder was positive.Difference was significant（P0.05）.Conclusion High expression of HIF-1α protein might have close relationship with genesis,development and relapse of bladder cancer.
作者 李然伟 任明 张明 温都苏 刘禄成
机构地区 吉林大学第二医院泌尿外科
出处 《中国实验诊断学》 2013年第6期1037-1038,共2页 Chinese Journal of Laboratory Diagnosis
基金 吉林省自然科学基金资助项目(201215077)
关键词 膀胱肿瘤 缺氧诱导因子-1Α 免疫组织化学 Bladdercancer Hypoxia-inducible factor-1 α Immunohistochemistry
分类号 R737.14 [医药卫生—肿瘤]
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参考文献9

  • 1Semenza GL,Wang GL. A nuclear factor induced hy hypoxia via de novo protein synthesis hinds to the human erythropoietin gene enhancer at a site required for transcriptional activation[J].Mol Cell Bio1,1992,12(12) :5447.
  • 2Adams JM, Difazio LT, Rolandelli RH, et al. HIF-l : a key media tor in hypoxia[J]. Acta Physiol Hung,2009,96 : 19.
  • 3Liu F,Wang P,Jiang X, et al. Antisense hypoxia inducible factor alpha gene therapy enhances the therapeutic efficacy of doxoruhi- cin to combat hepatocellular carcinoma[J]. Cancer Sci, 2010,99 (I0) ,2055.
  • 4Chai CY, Chen WT, Huang WC, et al. Hypoxia-inducible factor-1 alpha expression correlates with focal macrophage infiltration, an- giogenesis and unfavourable prognosis in urothelial carcinoma[J]. J Clin Pathol,2011,61(5) :658.
  • 5Blouw B,Song H,Tihan T,et al. The hypoxia response of tumor is dependent on their microenvironment[J].Cancer Cell, 2009,4: 133.
  • 6Oh SH, Woo J K, Jin Q, et al. Identification of "novel antiangiogen ic anticancer activities of deguelin targeting hypoxia-inducible fac- tor-1 alpha[J]. Int J Cancer,2010,122(1) :5.
  • 7Liu W,Shen SM, Zhao XY, et al. Targeted genes and interacting proteins of hypoxia inducible factor-l[J]. Int J Biochem Mol Biol, 2012,3:165.
  • 8Dang DT,Chun SY, Burkitt K, et al. Hypoxia-inducible factor-1 target genes as indicators of tumor vessel response to vascular en- dothelial growth factor inhibi-tion[J]. Cancer Res, 2009,68 (6): 1872.
  • 9Liao D,Corle C,Seagroves TN,et al. Hypoxia-indudble factor-1 alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression[J]. Cancer Research, 2010,67 : 563.

同被引文献20

  • 1Manolescu B, Oprea E, Busu C, et al. Natural compounds and the hypoxia-inducible factor (HIF) signalling pathway [J]. Biochimie, 2009, 91(11-12): 1347-1358.
  • 2Kimura S, Kitadai Y, Tanaka S, et al. Expression of hypoxia-induc- ible factor (HIF)-lalpha is associated with vascular endothelial growth factor expression and tumour angiogenesis in human oe- sophageal squamous cell carcinoma [J]. Eur J Cancer, 2004, 40(12): 1904-1912.
  • 3Befani C, Mylonis I, Gkotinakou IM, et al. Cobalt stimulates HIF-1-dependent But inhibits HIF-2-dependent gene expression in liver cancer cells [J]. Int J Biochem Cell Biol, 2013, 45(11): 2359-2368.
  • 4Theodoropoulos VE, Lazaris AC, Sofras F, et al. Hypoxia-inducible factor-1 α expression correlates with angiogenesis and unfavorable prognosis in bladder cancer [J]. Eur Urol, 2004, 46(2): 200-208.
  • 5Melstrom LG, Salabat MR, Ding XZ, et al. Apigenin down-regulates the hypoxia response genes: HIF-lct, GLUT-l, and VEGF in human pancreatic cancer ceils [J]. J Surg Res, 2011,167(2): 173-181.
  • 6Ord JJ, Agrawal S, Thamboo TP, et al. An investigation into the prognostic significance of necrosis and hypoxia in high grade and invasive bladder cancer [J]. J Urol, 2007, 178(2): 677-682.
  • 7Bedessem B, Stephanou A. A mathematical model of HIF-la-medi- ated response to hypoxia on the G1/S transition [J]. Math Biosci, 2014, 248: 31-39.
  • 8Streeter EH, Harris AL. Angiogenesis in bladder cancer-prognostic marker and target for future therapy . Surg Oncol, 2002, 11(1-2): 85-100.
  • 9Yan HT, Su GF. Expression and significance of HIF-1 α and VEGF in rats with diabetic retinopathy [J]. Asian Pac J Trop Med, 20t4, 7 (3): 237-240.
  • 10Chen MC, Lee CF, Huang WH, et al. Maguolol suppresses hypox- ia-induced angiogenesis via inhibition of H/F-1α./VEGF signaling pathway in human bladder cancer cells [J]. Biochem Pharmacol, 2013, 85(9): 1278-1287.

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中国实验诊断学
2013年 第6期

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