基于文本挖掘的流行性乙型脑炎用药规律研究

Exploration on Medication Regularity of Epidemic Encephalitis B with Text Mining Technique

目的利用文本挖掘技术探索流行性乙型脑炎(简称"乙脑")临床用药规律。方法检索中国生物医学文献数据库,收集有关乙脑文献数据,采用基于敏感关键词频数统计的数据分层算法,挖掘乙脑中药、中成药、西药及西药与中成药联合应用规律,并利用Cytoscape 2.8软件进行可视化展示。结果中药以生地黄、板蓝根、大青叶、生石膏、黄芩等清热解毒药最为常用;中成药以安宫牛黄丸、清开灵注射液等应用为多;西药以干扰素、利巴韦林等抗病毒药为基础,常常与其他抗病毒药、脑细胞营养药、激素类等药联合应用,这些西药也经常与安宫牛黄丸、清开灵等中成药联合应用。结论文本挖掘能够比较客观地总结疾病用药规律,为临床应用提供参考。

Objective To explore the clinical regularity of drugs on epidemic encephalitis B with text mining technique.Methods The data set on epidemic encephalitis B was downloaded from CBM database.The regularities of Chinese herbal medicine,Chinese patent medicine（CPM）,western medicine and the combination of CPM and western medicine on epidemic encephalitis B were mined by data slicing algorithm.The results are showed visually with Cytoscape 2.8 software.Results The main function of herbal pieces was focused on clearing heat and removing toxicity.The herbal pieces such as Rehmanniae Radix Isatidis Raxis,Isatids Folium,Paeoniae Radis rubra and Scutellariae Radix were most often used.Angong Niuhuang Wan and Qingkailing Injection were usually used as CPM.For western medicine,antiviral drugs such as interferon and ribavirin were often used,and they were often used together with brain cells nutrition medicine,hormone,immunopotentiator and so on,and they were also frequently used together with CPM such as Angong Niuhuang Wan and Qingkailing Injection.Conclusion Text mining approach provides an important method in exploring the medication regularity for diseas,and provide refenrence for clinical use.