Clusterin蛋白表达对卵巢癌预后的影响

The prognostic significance of Clusterin expression in ovarian cancer

目的探讨Clusterin蛋白表达对卵巢癌患者预后的影响。方法收集手术的181例卵巢癌患者的临床病理资料,分析Clusterin与卵巢癌相关临床病理因素的相关性及进行预后分析。结果卵巢癌Clusterin蛋白过度表达与组织学类型、病理分级和FIGO分期呈正相关,与发病年龄及TNM分期无关。Clusterin低表达和过度表达的平均生存时间分别为(89.7±0.3)个月和(70.3±0.8)个月(P=0.056)。结论 Clusterin与卵巢癌的不良预后因素有显著相关性,其可能在卵巢癌患者的疾病进展中发挥重要的作用,可作为指导预后的指标之一。

Objective To evaluate the prognostic value of clusterin expression in ovraian cancer.Methods The clusterin immunohistochemistry（IHC）,clinical data and pathological records of 181 patients,who were diagnosed with ovarian cancer between 1993 and 2004,were analyzed.Results The over-expression of clusterin protein in ovarian cancer tissues was significantly correlated with histological type,histological grade and FIGO stage;though with no significant correlation with age or PTNM status.The survivals in clusterin low-expression and over-expression patients were（89.7±0.3） and（70.3± 0.8） months,respectively（P=0.056）.Conclusion The clusterin in ovarian cancer patients correlates with adverse prognostic factors and plays an important role in progression of disease,providing a novel prognostic predictor.