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Pitx2基因与心房颤动 被引量：2

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摘要 心房颤动（以下简称房颤）是临床上最常见的持续性心律失常,该病严重危害人类健康,轻者影响生活质量,重者可致残、致死,其危害主要表现为血流动力学不稳定导致心、脑等重要器官供血障碍,最常发生脑卒中,所以关于房颤发病机制及治疗的研究（GWAS）已成为目前临床研究热点。房颤相关致病基因和易感基因的确定为阐明房颤的分子机制提供了线索。
作者 李腾 吴书林
机构地区 广东省心血管病研究所 广东省人民医院(广东省医学科学院)心内区
出处 《广东医学》 CAS CSCD 北大核心 2013年第11期1782-1784,共3页 Guangdong Medical Journal
关键词 心房颤动 易感基因 血流动力学不稳定 持续性心律失常 相关致病基因 临床研究 人类健康 生活质量
分类号 R541.75 [医药卫生—心血管疾病]
  • 相关文献

参考文献22

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二级参考文献15

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  • 4MOMMERSTEEG M T, BROWN N A, PRALL O W, et al. Pitx2e and Nkx2-5 are required for the formation and identity of the pulmonarymyocardium[J]. Circ Res, 2007, 101(9): 902-909.
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  • 6KAAB S, DARBAR D, VAN NOORD C, et al. Large scale replication and meta analysis of variants on chromosome 4q25 associated with atrial fibrillation[J]. Eur Heart J, 2009, 30 (7) : 813-819.
  • 7WANG J, KLYSIK E, SOOD S, et al. Pitx2 prevents susceptibility to atrial arrhytbmias by inhibiting left sided pacemaker specification[J]. Proc Natl Aead Sci U S A, 2010, 107(21):9753- 9758.
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  • 10MOMMERSTEEG M T, HOOGAARS W M, PRALL O W, et al. Molecular pathway for the localized formation of the sinoatrialnode[J]. Cire Res, 2007, 100(3): 354-362.

共引文献1

同被引文献23

  • 1Keating MT, Sanguinetti MC. Molecular and cellular mechanisms of cardiac arrhythmias. Cell, 2001, 104:569-580.
  • 2Sinner MF, Ellinor PT, Meitinger T, et al. Genome-wide associationstudies of atrial fibrillation:past, present, and future. Cardiovasc Res, 2011, 89:701-709.
  • 3Gudbjartsson DF, Arnar DO, Helgadottir A, et al. Variants conferringrisk of atrial fibrillation on chromosome 4q25. Nature, 2007, 448:353-357.
  • 4Kalinderi K, Fraqakis N, Koskinas KC, et al. Association Between rs2200733 Polymorphism on Chromosome 4q25 and Atrial Fibrillation in a Greek Population. Hellenic J Cardiol, 2015, 56:224-229.
  • 5Viviani Anselmi C, Novelli V, Roncarati R, et al. Association of rs2200733 at 4q25 with atrial flutter/fibrillation diseases in an Italianpopulation. Heart, 2008, 94 : 1394-1396.
  • 6Gretarsdottir S, Thorleifsson G, Manolescu A, et al. Risk variantsfor atrial fibrillation on chromosome 4q25 associate with ischemicstroke. Ann Neurol, 2008, 64:402-409.
  • 7Lemmens R, Buysschaert I, Geelen V, et al. The association of the4q25 susceptibility variant for atrial fibrillation with stroke is limitedtostrokeof cardioembolic etiology. Stroke, 2010, 41:1850-1857.
  • 8Wnuk M, Pera J, Jagietta J, et al. The rs2200733 variant on chromosome 4q25 is a risk factor for cardioembolicstroke related to atrial fibrillation in Polish patients. Neurol Neurochir Pol, 2011, 45:148-152.
  • 9Rollo J, Knight S, May HT, et al. Incidence of dementia in relation to genetic variants at PITX2, ZFHX3, and ApoE e 4 in atrial fibrillation patients. Pacing Clin Electrophysiol, 2015, 38:171-177.
  • 10Shi L, Li C, Wang C, et al. Assessment of association ofrs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke ina Chinese Han population. Hum Genet, 2009, 126:843-849.

引证文献2

二级引证文献3

广东医学
2013年 第11期

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