峡视核——研究中枢神经系统发育及细胞凋亡的新模型

The Isthmo-optic Nucleus:a New Model to Study the Development and Apoptosis of Central Nervous System

鸟类离中系统的峡视核是近年来研究中枢神经系统发育过程中细胞凋亡的新模型 .在其发育过程中 ,随着核团的形成、折叠及分层 ,伴有一些与峡视核相关的临时神经通路的形成和消失 ,与此同时 ,该核团中神经元有一半以上发生细胞凋亡 .研究表明 ,形成正确的传入和传出联系对神经元的存活十分重要 .分子水平上的机制研究揭示 ,细胞凋亡与一系列神经营养因子及其相应的受体相关 .细胞凋亡对中枢神经系统发育过程中正确神经通路的形成有重要意义 .

In recent years, the isthmo optic nucleus (ION) in the avian centrifugal system became a new model to study the apoptosis and the development of central nervous system (CNS). During its development , together with the formation, folding and laminating of the nucleus, there exist some temporal pathways linked to the nucleus. More than half of its neurons befall apoptosis in this period. Researches show that proper efferent and afferent projections are essential to the survival of neurons. The molecular mechanism indicates that apoptosis is related to a series of neurotrophins and their receptors . Apoptosis plays an important role in the development of CNS.