长期低剂量克拉霉素联合布地奈德治疗慢性鼻窦炎临床研究

Clinical Research on Long-Term Low-Dose Clarithromycin Combined with Budesonide Spray in Treating Chronic Rhinosinusitis

目的观察长期低剂量克拉霉素联合布地奈德喷雾剂治疗慢性鼻窦炎的疗效。方法将84例患者随机分为观察组44例和对照组40例,观察组采用长期低剂量克拉霉素联合布地奈德喷雾剂治疗,对照组单用布地奈德喷雾剂治疗,治疗前后采用视觉模拟量表(VAS)、鼻窦CT评分和糖精传输时间(ST)进行疗效评价。结果两组治疗1个月后的VAS评分、鼻窦CT评分和ST均明显降低(P<0.01),但组间无明显差异(P>0.05);两组治疗3个月后的VAS评分、鼻窦CT评分和ST均明显降低(P<0.01),且观察组降低更明显(P<0.01),且在整个服药期间未发现任何患者有严重的不良反应。结论长期低剂量克拉霉素联合布地奈德喷雾剂治疗慢性鼻窦炎安全有效。

Objective To observe the effect of long-term low-dose clarithromycin combined with Budesonide Spray in the treatment chronic rhinosinusitis. Methods 84 cases of chronic rhinosinusitis were randomly divided into the observation group（44 cases）and the control group（40 cases）. The observation group adopted long-term low-dose clarithromycin combined with Budesonide Spray treat- ment,while the control group adopted single Budesonide Spray treatment. The visual analogue scale（VAS）scores before and after treat- ment,nasal sinus CT scores and saccharin transmission time（ST）were adopted for the effective evaluation. Results The VAS scores at 1 month after treatment,nasal sinus CT scores and ST in both groups were reduced significantly（P 〈 0.01）,but the differences be- tween two groups were not statistically significant（P 〉 0.05）. The VAS scores,sinus CT scores and ST at 3 months after treatment in both groups were reduced significantly（P 〈 0. 01）,but which in the observation group were more significant, the differences showing statistical significance（ P 〈 0. 01 ）. In the period of medication, no cases had serious adverse reactions. Conclusion Long- term low- dose clarithromycin combined with Budesonide Spray is safe and effective in the treatment of chronic rhinosinusitis.