咽舒宁颗粒抗炎药效试验研究

Anti-inflammatory effect of Yanshuning Granules

目的观察咽舒宁颗粒的抗炎作用。方法将实验动物随机分为对照、阳性药和咽舒宁颗粒高、中、低剂量组(8.25,4.12,2.06 g.kg-1),ig 7 d,采用醋酸致小鼠腹腔毛细血管通透性实验、角叉菜胶性足肿胀实验和棉球肉芽肿实验,观察其对不同炎症模型的作用。结果咽舒宁颗粒能明显抑制醋酸致小鼠腹腔毛细血管通透性增高(P<0.05或P<0.01);显著抑制大鼠角叉菜胶性足肿胀程度(P<0.05或P<0.01)和大鼠棉球肉芽肿的形成(P<0.05或P<0.01)。结论咽舒宁颗粒具有明显的抗急慢性炎症作用。

OBJECTIVE To study the anti-inflammatory effect of Yanshuning Granules. METHODS Mice were divided into six groups randomly：normal control group, two positive groups, high dose group, middle dose group and low dose group of Yanshuning granules（8.25,4. 12,2.06 g· kg^-1 ） ,after 7d by ig administration. The effects of Yanshuning Granules on different inflammation models were studied by mice acetic acid-induced celiac capillary permeability,earrageenan-induced rat foot edema and cotton pellet-induced granuloma. RESULTS Yanshuning Granules could significantly inhibite the degree of the increase in celiac capillary permeability（ P 〈 0. 05 or P 〈 0. 01 ）, markly inhibit the degree of the increase in carrageenan-induced rat foot edema（P 〈 0. 05 or P 〈 0. 01 ） and obviously reduce cotton pellet-induced granuloma（P 〈0. 05 or P 〈0. 01 ）. CONCLUSION Yanshuning Granules has significant resistance of acute or chronic inflammation.