泄殖腔感染鸡传染性支气管炎病毒的临床试验

Clinical Infectious Test of Infectious Bronchitis Virus by Cloaca

本试验选用鸡传染支气管炎强毒 M41株 ,通过泄殖腔和滴鼻两种途径对 7日龄 SPF鸡进行了临床感染试验。经临床观察、病理解剖和病毒分离证明泄殖腔是传染性支气管炎病毒 ( IBV)感染鸡的一种途径。尽管两种感染途径引起试验鸡的发病率相同 ,但在组织器管的致病性和病毒分离方面存在明显差异。经泄殖腔感染鸡的肾病变发生率和肾脏中 IBV的分离率均为 1 7.9%,而经滴鼻感染鸡的肾病变发生率和肾脏中 IBV的分离率均为 3.6%。经泄殖腔感染和滴鼻感染鸡的肺脏中 IBV的分离率分别为 35.7%和 64.2 %。这些结果表明 ,IBV对组织器官的致病性与其感染途径有关 。

The avian infectious bronchitis virus(IBV)virlulent strain M41 was used in this study. The clinical infectious test of 7 day old chicken was carried with two ways of cloaca inoculation and intranasal inoculation. It was identified that the cloaca rute was an infectious way of IBV by clinical observation、pathoanatomy and virus isolation. All though the morbidity rates of the two ways were same, there was much different in pathogenicity and virus isolation. The morbidity rate of nephrosis and the virus isolation rate of kideny were 17.9% by the cloaca inoculation,but they were 3.6% by the intranasal inoculation. The isolation rates of lung were 35.7% and 64.2% separately by the cloaca inocalation and intranasal rute. The rasults showed there was a relationship between pathogenicity and infectious rute. This gave us a new idea of study on IB pvevention and pathogenesis.