米索前列醇和米非司酮用于终止妊娠的进展研究

Progress research of misoprotol cooperating with mifepristone on the termination of pregnancy

过去对于孕期要求终止妊娠的患者常常采用钳刮术或宫腔内注射利凡诺进行引产,但是钳刮术对患者的损伤较大,易出现大量出血或感染等并发症,严重的还会出现子宫穿孔、羊水栓塞或宫颈裂伤等症状,而选择药物引产法则将药液注入患者的宫腔内,如果患者孕周少,羊水量不足就需要等待孕周够大才可以引产,这就加重了患者的心理负担。而近几年米非司酮配伍使用米索前列醇在妇科临床上被广泛的应用,主要的作用是人工流产或引产。米非司酮是孕激素拮抗剂,而米索前列醇具有软化宫颈、兴奋子宫的作用,本文就米索前列醇与米非司酮在临床上的作用机制、安全性及临床效果等进行简要阐明。

Curettage or induction of rivanol injected into amniochorial cava were usually used for the patients requesting for termination of pregnancy yesterday.But the damage of curettage is bigger,such as appearing the complications of excessive bleeding or infection easily and perforation of uterus or amniotic embolism or laceration of cervix seriously.While drug induction is that make drug inject into amniochorial cava, the induction is used until gestational weeks longer if the patients have few gestational weeks and amniotic fluid shortage.These add to psychological burden of patients.Misoprotol cooperating with mifepristone are widely used for abortion and induction in clinical gynecology in recent years.Mifepristone is progesterone receptor antagonist,while misoprotol has the effect of intenerating cervix and exciting uterus.This study introduces briefly the mechanism of action,safety and clinical effect of misoprotol cooperating with mifepristone.