氟康唑治疗老年口腔念珠菌40例临床观察

The clinical effect of fluconazole in treatment of 40 cases elderly oral candidiasis

目的观察氟康唑在治疗老年口腔念珠菌的临床效果。方法选取我院2011年10月～2012年4月老年口腔白念珠菌患者80例,按照患者本人的用药情况将其分为观察组和对照组各40例。观察组给予氟康唑治疗,对照组给予制霉菌素治疗,比较两组患者的临床疗效。结果观察组的总有效率95.0%明显高于对照组87.5%,但差异无统计学意义(P>0.05);停药6个月进行复查,观察组复发率(27.5%)明显低于对照组(47.5%),差异有统计学意义(P<0.05)。结论氟康唑和制霉菌素单纯使用在治疗老年口腔念珠菌病上均有疗效,但氟康唑是长期疗效的首选药物。

Objective To explore the the clinical effect of Fluconazole in treatment of elderly oral candidiasis. Methods Selected 80 elderly patients with oral candidiasis from Oct. 2011 to Apr.2012 in our hospital were divided into observation group and control group （each 40 cases ） according to patients＂ determination. The observation group was given Fluconazole,and the control group was given Nystatin, the clinical effect of both groups were observed and compared. Results The total effect rate in observation group（95.0%） was higher than that in control group（87.5%）,with non-significant difference（P 〉 0.05）;The total patients were reexamined 6 months after discontinuation when the skin lesions and other symptoms disappeared, The recurrence rate in observation group （27.5%）was obviously lower than that in control group （47.5%）,with significant difference（P 〈 0.05）. Conclusion Fluconazole and Nystatin both can treat elderly oral candidiasis, but Fluconazole is the preferred drug for lon-term effect in elderly patients.