神经生长因子及受体在肿瘤中的表达及临床意义

Expressions and clinical significance of nerve growth factor and its receptor in tumors

神经生长因子(NGF)是一种多功能的神经营养因子,与特异的靶细胞表面的神经生长因子受体结合,介导产生一系列的生物学效应。目前研究表明NGF及其受体与肿瘤的增殖、分化、凋亡、血管形成、转移及预后也密不可分,且由NGF介导的信号通路已成为肿瘤治疗新的靶点。

Never growth factor is a multi-function neurophic factor. It produces a series of biological effects through the nerve growth factor receptors on the specific target cell surface. It plays an important role on biological processes of nervous system. Many current researches have showed that NGF and its receptors are closely related with the proliferation, differentiation, apoptosis, angiogenesis, transfer and prognosis of tumors. The signal path of NGF has already become a new target in tumor treatment. This paper is about the progress of studies of nerve growth factor and its receptors and tumors.