摘要
目的:总结国内外关于缺氧诱导因子-1(HIF-1)、上皮细胞-间质转化(Epithelial-mesenchymal tran-sition,EMT)在乳腺癌的浸润、转移中的作用,探讨HIF-1对EMT相关蛋白的调节作用。方法:应用CNKI、PUBMED全文数据库检索系统,以"HIF-1、EMT、TWIST、CAIX、N-cad、泛素、HIF-1与EMT"等为关键词检索相关文献。纳入标准:1)HIF-1的节构及功能;HIF-1在肿瘤生长、浸润、转移中的作用;2)EMT的特征及在肿瘤浸润、远处转移中的作用;3)HIF-1对EMT相关蛋白的调节。符合标准并纳入的分析文献23篇。结果:HIF-1、CAIX是肿瘤细胞缺氧的标志,在肿瘤的生长、浸润和转移过程中发挥重要作用;EMT亦参与了肿瘤的浸润和转移;HIF-1通过不同的通路对EMT相关蛋白进行调节。结论:探讨HIF-1对EMT相关蛋白的调节作用,有望为乳腺癌提供新的治疗方案。
Objective：To summarize the effect of HIF-1 and EMT in tumor＇ s infiltration and metastasis of Breast Cancer and discuss the moderating effects of HIF-1 on EMT and its associated- proteins. Methods： Using ＂HIF- 1, EMT, TWIST, CAIX, N - cad, Ubiquitin, HIF - 1 -1 EMT＂ as key words searched in CNKI and PUBMED database. Totally 23 papers were selected and analyzed according to the inclusion criteria as follows ： （ 1 ） The structure and function of HIF- 1 ; and its roles in tumor＇ s growth, infiltration and metastasis. （2） Characteristics of EMT and its affects in infiltration and remove metastasis of Cancer. （3）The regulating effects of HIF-1 on EMT and its associated-proteins. Results ： HIF- 1 is hypoxia symbol of tumor cells which plays important role in tumor＇ s growth and pro- gression as well as metastasis. Epithelial-mesenchymal transition also participates in this process. HIF- 1 regulates the associated-proteins of EMT through different signafing-ways. Conclusion ： Investigating the effects of HIF-1 on EMT and its associated-proteins may provide a new therapy for Breast Cancer.
出处
《内蒙古医科大学学报》
2013年第3期247-252,共6页
Journal of Inner Mongolia Medical University
基金
国家自然科学基金项目(30860331)
