同时性肝转移结直肠癌的临床特征分析

Synchronous liver metastasis in patients with colorectal cancer:a clinical analysis

目的:探讨同时性肝转移结直肠癌患者的临床病理因素。方法:回顾性分析2005年1月至2010年12月南方医科大学第三附属医院收治的156例结直肠癌患者的临床资料,分析临床因素与同时性肝转移的关系。结果:156例结直肠癌患者中18例(11.5%)发生同时性肝转移。直肠是结直肠癌的最常见的原发部位。同时性肝转移的发生与年龄、性别、肿瘤大小、肿瘤原发部位及肿瘤分化程度无相关性(P>0.05),而与肿瘤病理分期、淋巴结转移、CEA水平及血管浸润有相关性(P<0.05)。结论:肿瘤病理分期、淋巴结转移、CEA水平及血管浸润等因素与同时性肝转移存在相关性。

Objective：To investigate the influencing factors of synchronous colorectal liver metastasis in patients with colorectal cancer. Methods： We retrospectively analyzed the clinical profiles of 156 patients with colorectal cancer （CRC） who were admitted to The Third Affiliated Hospital of Southern Medical University between January 2005 and December 2010. This entailed subsequent analysis on the relationship between the clinical factors and synchronous metastasis. Results： Of the 156 patients with colorectal cancer, synchronous liver metastasis was found in 18 cases （ 11.5% ） , with the colon being recognized as the most frequent location of involvement. The presence of synchronous liver metastasis was associated with the pathological stage, lymph node metastasis, the level of CEA and presence of vascular invasion （ all P 〈 0.05） , but not the age, sex, size of tumor, primary location or differentiation of tumor （ all P 〉 0.05 ）. Conclusion ： The incidence of synchronous liver metastasis is associated with the pathological stage, lymph node metastasis, the level of CEA and presence of vascular invasion.