线粒体电压依赖性阴离子通道与心血管疾病

Voltage-dependent Anion Channel and Cardiovascular Diseases

电压依赖性阴离子通道(VDAC)是位于线粒体外膜的通道蛋白,是线粒体与细胞质之间转运ATP以及其他代谢产物的主要通道,在线粒体代谢和细胞生长中发挥重要调控作用。近期研究发现,在心肌缺血再灌、糖尿病、心衰、高血压和动脉粥样硬化时,VDAC表达明显增加,引起细胞内钙离子循环紊乱、氧化应激,进而导致细胞凋亡,已成为心血管疾病研究的新热点。本文就VDAC的分子功能,调控及其在心血管疾病中的作用和相关机制进行综述。

The voltage-dependent anion channel （VDAC）, a mitochondrial membrane channel protein located in the outer of mitochondrial membrane, is the main pathway between mitochondria and cytoplasm exchanging ADP, ATP, and other metabolites, and plays an important role in mitochondrial metabolism and cell growth. A growing evidence showed that VDAC was increased in cardiovascular diseases including myocardial ischemia and reperfusion, diabetes, heart failure, hypertension and atherosclerosis. The abnormal state of VDAC will result in cell death by inducing calcium cycling dysfunction and oxidative stress. And VDAC has become a hot topic in the field of cardiovascular diseases research. In this article, we will introduce the molecular function and regulation of VDAC and its role in cardiovascular diseases.