皮肤浆细胞增生症1例及相关文献复习

A Case Report of Cutaneous Plasmacytosis and Review of the Relative Literature

皮肤浆细胞增生症是一种罕见的疾病,其特征主要是皮肤良性多克隆浆细胞浸润,通常与多克隆γ-球蛋白血症相关。其典型的临床表现为红褐色斑、斑块或结节,高γ-球蛋白血症,一半以上的患者伴有不同程度的淋巴结病。据以往文献报道,此病主要发生于日本中老年人群。截止到目前为止,关于中国人皮肤浆细胞增生症的报道尚少。在此报道52岁的中国女性浆细胞增生症1例,并复习以往相关文献,对其流行病学、临床特征、病理特点、病因病机、诊断、治疗及预后等进行总结分析。

Cutaneous plasmacytosis is a uncommon disorder,which typically manifests with red-brown macules to plaques, polyclonal hypergammaglobulinemia, and variable degrees of lymphadenopathy and hepatosplenic involvement. The histologically findings show marked hyperplasia of mature plasma cells. This condition has been primarily described in the middle-aged Japanese population. Herein, we describe a 52-year-old patient of Chinese origin suffering cutaneous plasmacytosis and review the previous literature, and discuss the characteristic clinical and pathologic features of cutaneous plasmacytosis on details finally.