摘要
目的:观察生存素(Survivin)、脆性组氨酸三联体基因(fragile histidine triad,FHIT)及张力蛋白同源定位于第10号染色体上丢失的磷酸酶基因(phosphatase and tensin homologydeleted on chromosome 10,PTEN)在宫颈癌组织的表达及意义。方法:采用免疫组织化学方法检测Survivin、FHIT及PTEN在40例宫颈癌组织和36例正常宫颈组织中的表达,并分析其与宫颈临床病理的关系及三者之间的相关性。结果:Survivin、FHIT及PTEN在宫颈癌组织和正常宫颈组织中阳性表达率差异具有统计学意义(P<0.01);Survivin阳性表达率与宫颈癌的临床分期、淋巴转移、病理分级相关(P<0.05),而与年龄、组织学类型无相关性(P>0.05);FHIT和PTEN的阳性表达率与宫颈癌有无淋巴转移和病理分级相关(P<0.05),而与年龄、临床分期、组织学类型无相关性(P>0.05);宫颈癌组织中Survivin与FHIT和PTEN的表达水平呈负相关(P<0.01),而FHIT和PTEN表达水平呈正相关(P<0.05)。结论:联合检测Survivin、FHIT及PTEN对宫颈癌的诊断及预后判断有一定的价值。
Objective: To observe the expressions of survivin, FHIT and PTEN in human cervical carcinoma tissues, and to analyze the relationship among their expression levels and the elinicopatho- logic parameters of cervical carcinoma, and to explore their roles in the genesis and development of cervical carcinoma. Methods: Immunohistochemistry technique was adopted to test the expressions of survivin, FHIT, and PTEN in 40 cervical cancer tissues and 36 normal cervical tissues, and the rela- tions among their expressions and clinicpathological parameters of cervical cancer and the correlation a- mong themselves were analyzed. Results:l. Statistical differences were found in the positive expression rates of survivin, FHIT, and PTEN between cervical cancer tissues and normal cervical tissues ( P 〈 0. 01 ). 2. The positive expression rate of survivin was correlated to the clinical stage, lymphatic me- tastasis, and histological grade ( P 〈 0.05 ), but was not correlated to age and histological type ( P 〉 0.05 ). The positive expression rates of FHIT and PTEN were correlated to lymphatic metastasis, and histological grade (P 〉 0.05 ), but were not correlated to age, clinical stage and histological type ( P 〈 0. 05). 3. The expression level of survivin in cervical cancer tissue was negatively correlated with that of FHIT and PTEN (P 〈 0.01 ) respectively, while the expression levels of FHIT and PTEN were positively correlated (P 〈 0.05 ). Conclusion: There is certain guiding value of combined detection of survivin, FHIT, and PTEN in diagnosis and prognosis of cervical cancer.
出处
《贵阳医学院学报》
CAS
2013年第3期261-264,268,共5页
Journal of Guiyang Medical College