Survivin、FHIT及PTEN在宫颈癌中的表达及意义

The Expressions and Clinical Significances of Survivin, FHIT and PTEN in Cervical Carcinoma

目的:观察生存素(Survivin)、脆性组氨酸三联体基因(fragile histidine triad,FHIT)及张力蛋白同源定位于第10号染色体上丢失的磷酸酶基因(phosphatase and tensin homologydeleted on chromosome 10,PTEN)在宫颈癌组织的表达及意义。方法:采用免疫组织化学方法检测Survivin、FHIT及PTEN在40例宫颈癌组织和36例正常宫颈组织中的表达,并分析其与宫颈临床病理的关系及三者之间的相关性。结果:Survivin、FHIT及PTEN在宫颈癌组织和正常宫颈组织中阳性表达率差异具有统计学意义(P<0.01);Survivin阳性表达率与宫颈癌的临床分期、淋巴转移、病理分级相关(P<0.05),而与年龄、组织学类型无相关性(P>0.05);FHIT和PTEN的阳性表达率与宫颈癌有无淋巴转移和病理分级相关(P<0.05),而与年龄、临床分期、组织学类型无相关性(P>0.05);宫颈癌组织中Survivin与FHIT和PTEN的表达水平呈负相关(P<0.01),而FHIT和PTEN表达水平呈正相关(P<0.05)。结论:联合检测Survivin、FHIT及PTEN对宫颈癌的诊断及预后判断有一定的价值。

Objective： To observe the expressions of survivin, FHIT and PTEN in human cervical carcinoma tissues, and to analyze the relationship among their expression levels and the elinicopatho- logic parameters of cervical carcinoma, and to explore their roles in the genesis and development of cervical carcinoma. Methods： Immunohistochemistry technique was adopted to test the expressions of survivin, FHIT, and PTEN in 40 cervical cancer tissues and 36 normal cervical tissues, and the rela- tions among their expressions and clinicpathological parameters of cervical cancer and the correlation a- mong themselves were analyzed. Results：l. Statistical differences were found in the positive expression rates of survivin, FHIT, and PTEN between cervical cancer tissues and normal cervical tissues （ P 〈 0. 01 ）. 2. The positive expression rate of survivin was correlated to the clinical stage, lymphatic me- tastasis, and histological grade （ P 〈 0.05 ）, but was not correlated to age and histological type （ P 〉 0.05 ）. The positive expression rates of FHIT and PTEN were correlated to lymphatic metastasis, and histological grade （P 〉 0.05 ）, but were not correlated to age, clinical stage and histological type （ P 〈 0. 05）. 3. The expression level of survivin in cervical cancer tissue was negatively correlated with that of FHIT and PTEN （P 〈 0.01 ） respectively, while the expression levels of FHIT and PTEN were positively correlated （P 〈 0.05 ）. Conclusion： There is certain guiding value of combined detection of survivin, FHIT, and PTEN in diagnosis and prognosis of cervical cancer.