血清抗衰老因子klotho水平与急性心肌梗死发生的关系

Relation of serum Klotho level and acute myocardial infarction

目的探讨抗衰老因子klotho与急性心肌梗死发生的关系。方法对92例急性心肌梗死患者(病例组)与114例对照者(对照组)进行危险因素调查,采用ELISA法测定血清klotho表达水平。结果病例组吸烟、高血压、糖尿病比例高于对照组(P均<0.05),而血清klotho水平则低于对照组(中位数32 pg/ml比43 pg/ml,P<0.001)。以klotho血清值的中位数37 pg/ml作为分界值,高血清klotho的OR值为0.345(95%CI:0.171～0.693)。结论血清klotho表达水平可能与急性心肌梗死的发生相关,血清klotho蛋白高表达可能有降低急性心肌梗死发生的作用。

Objective To explore the relation between the anti-aging factor klotho and acute myocardial infarction （AMI）. Methods Risk factors of AMI were investigated in 92 patients with AMI and 114 controls. The expression level of serum klotho were determined by ELISA in both groups. Results The co-morbidities of smoking, hypertension, diabetes mellitus were significantly higher in the AMI group than in the controls. The median of serum klotho in AMI group was 32 pg/ml, while the median in the controls 43 pg/ml （Z = - 5. 258, P 〈 0. 001 ）. Taken the median of serum klotho 37 pg/ml as the cut point, the OR of high serum klotho for AMI is 0. 345 （95% CI： 0. 171 - 0. 693 ）. Conclusions The expression level of serum klotho was potentially associated with AMI, and the high level of serum klotho expression might reduce the risk of AMI.