86例帕金森病患者非运动症状的临床研究

Non-motor symptoms in 86 patients with Parkinson's disease

目的探讨帕金森病(PD)患者非运动症状(NMS)的发生与分布情况及其可能的影响因素。方法对86例PD患者进行NMS问卷(NMS Quest)调查,统计各种NMS的发生率,并对发生率最高的3个症状与性别、病程、H-Y分级及临床分型进行统计学分析。结果全部PD患者中NMS的发生率为96.5%,以便秘、尿频尿急、不宁腿综合征(RLS)最常见。便秘症状男性与女性、病程≤5年与>5年者、临床分型之间相比,差异有显著性意义(P<0.05);尿频尿急症状男性与女性、病程≤5年与>5年者之间相比,差异有显著性意义(P<0.05);而3者的发生均随H-Y分级的增加而增加。结论 PD患者NMS的发生率非常高,以便秘、尿频尿急和RLS最为常见。性别、病程及H-Y分级是影响便秘及尿频尿急的重要因素,随着PD病情进展,3者的发生率也大大提高。

Objective To discuss the incidence and the distribution of non-motor symptoms（NMS） in Parkinson＇s disease（PD） and the possible impact factors.Methods The NMS questionnaire（NMS Quest） was administered to 86 patients with PD,calculating the incidence of the varying NMS,the top 3 items of NMS were statistically analyzed with sex,course of disease,Hoehn-Yahr（H-Y） grade and clinical type.Results The total incidence rate of non-motor symptoms of Parkinson＇s disease was 96.5%,constipation,urinary frequency and urgency,restless legs（RLS） were the top 3 items of NMS.According to the incidence,there were significant different in constipation between man and woman,course ≤5 and 5years,rigidity and tremor type（P0.05）,urinary frequency and urgency between man and woman,course ≤5 and5years（P0.05）.And the incidence of these 3 symptoms are greatly increased with the H-Y grade rising.Conclusion NMS in PD are common,constipation,urinary frequency,urinary urgency,and RLS are the top 3 items of NMS.Among them,sex,course of disease and H-Y grade are the important factors,and with H-Y grade of PD rising,the incidence of them are increased.