国产法罗培南钠片治疗呼吸道细菌感染的临床疗效

Clinical efficacy of domestic faropenem sodium tablets on bacterial respiratory tract infection

目的评价国产法罗培南钠片治疗呼吸道细菌性感染的疗效和安全性。方法采用随机、双盲、对照临床研究，选择70例呼吸道细菌性感染患者，随机分为试验组35例给予法罗培南钠片和对照组35例给予头孢呋辛酯片。给药方案均为每次1片，每日3次，口服，疗程7～14d。结果试验组和对照组的痊愈率分别为77．14％和74．29％，有效率分别是94．29％和91．43％，两组疗效比较差异无统计学意义（P〉0．05）。试验组和对照组细菌清除率分别是96．67％和93．10％，差异无统计学意义（P〉0．05）。不良反应发生率分别为8．57％和5．71％，差异无统计学意义（P〉0．05）。结论国产法罗培南钠片治疗细菌性呼吸道感染安全、有效。

Objective To evaluate the clinical efficacy and safety of domestic faropenem sodium tablets in the treatment of bacterial respiratory tract infection. Methods A total of 70 patients with re- spiratory infection were enrolled into this randomized controlled clinical study, including 35 patients received domestic faropenem sodium tablets as the trial group and 35 patients received cefuroxime axetil tablets as the control group. Every individual in both groups was orally given one tablet three times the day, the course was 7 to 14 days. Results The cure and effective rates were 77. 14% and 94.29% in trial group, 74.29% and 91.43% in control group. The bacterial eradication rates were 96.67% vs 93. 10% and the adverse events rates were 8.57% vs 5.71% in the trial and control groups, respectively. There were no significant differences between the two groups （ P 〉 0. 05 ）. Conclusions Domestic faropenem sodium tablets is effective and safe for the treatment of bacterial respiratory tract infections.