液基细胞学技术与传统细胞学涂片技术对宫颈病变细胞学的诊断价值

Diagnosis value of liquid-based cytology and conventional cytology smears on detecting cervical squamous cell lesions

目的比较液基细胞学技术与传统细胞学涂片在宫颈鳞状细胞病变检测中的价值。方法对2009年10月至2012年10月1200例妇女采用宫颈液基细胞学或传统细胞学涂片进行筛查，并对筛查阳性病例以其阴道镜检查及病理活检结果为金标准作为阳性对照，评估液基细胞学技术对宫颈不同病变的诊断价值。结果宫颈液基细胞学筛查出ASCUS／A—GUS及以上分级病例96例，阳性检出率为16．00％；传统细胞学涂片筛查出巴氏ⅡB级及以上分级病例29例，阳性检出率为4．83％；宫颈液基细胞学阳性检出率明显高于传统细胞学涂片，差异有统计学意义（P〈0．05）。以阴道镜及病理组织学检查结果为金标准，宫颈液基细胞学筛查符合率为76．80％，传统细胞学涂片筛查符合率为38．16％，两组比较差异有统计学意义（P〈0．05）。结论液基细胞学技术筛查宫颈鳞状细胞病变明显优于传统细胞学涂片。

Objective To compare the value of liquid-based cytology and conventional cytology smears on detection of cervical squamous cell lesions. Methods One thousand and two hundred women were detected by cervical liquid-based cytology and conventional cytology smear screening from Oct. 2009 to Oct. 2012, of which positive eases were detected by colposcopy and biopsy as the gold standard as a positive control. The diagnostic value of the liquid-based cytology on cervical lesions was assessed. Resuits The positive detection rate of ASCUS/A-GIJS and above lesions was 16. 00% （96 cases） by liquid-based cytology detection, and positive detection rate of pap IIB level and above lesions was 4. 83% （29 cases）. The positive detection rate by liquid-based cytology was significantly higher than that of conventional cytology smears, the difference was statistically significant （P 〈 0. 05）. Colposcopie and histopathologieal findings as the gold standard, cervical liquid-based cytology screening coincidence rate was 76.80%, conventional cytology smear screening coincidence rate was 38.16%, and the difference was statistically significant （P 〈 0. 05 ）. Conclusions Liquid-based cytology screening for eervieal squamous cell lesions is significantly superior to conventional cytology smears.