硬毛地笋化学成分研究

Chemical Constituents of Lycopus lucidus Turcz.var.hirtus Regel

采用各种色谱对硬毛地笋(Lycopus lucidus Turcz.var.hirtus Regel)的化学成分进行分离,通过理化性质和波谱分析进行结构鉴定。从硬毛地笋全草甲醇提取物中分离鉴定了9个化合物:β-胡萝卜素(1),7,3',4'-三羟基黄酮(2),β-谷甾醇(3),3',4',5-三羟基-3,7-二甲氧基黄酮(4),α-香树脂醇(5),β-香树脂醇(6),24-羟基-乌苏-12-烯-28-酸(7),β-胡萝卜苷(8),24-甲基-5α-胆甾-7,22-二烯-6α-醇-3β-O-葡萄糖苷(9)。化合物4,7和9为首次从该科植物中分离得到,化合物1～9均为首次从硬毛地笋中分离得到。

The chemical constituents of Lycopus lucidus Turcz. var. hirtus Regel were studied using all kinds of chromato- graphic techniques,and the structures were identified on the basis of physic-chemlcal and spectroscopeic technology. Nine compounds were isolated from the methanol extract of L. lucidus Turcz. var. hirtus Regel. These structures were elucidated as E-carotene （ 1 ）, 7,3＇, 4＇-trihydroxyflavone （2） ,β-sitosterol （ 3 ）, 3＇, 4＇, 5-trihydroxy- 3,7-methoxy-flavone （4）, α-amyrin （5）,β-amyrin （6）, 24-hydroxy-urs-12-en-28-oic acid （7）,β-daucosterol （ 8 ）, 24-methyl-5 a-cholesta- 7,22-dien-6α-ol-3β-O-glucopyranosyl （9）. Compounds 4,7 and 9 were isolated for the first time from Lamiaceae. All compounds were isolated from this plant for the first time.