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克拉屈滨的临床应用 被引量：10

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摘要 1978年，Cohen等研究发现腺苷脱氨酶（ADA）生成缺陷可以导致三磷酸脱氧腺苷（dATP）在细胞内有毒蓄积并进而引起特异性的淋巴细胞死亡。
作者 杜雅慧 王文 纪春岩
机构地区 山东大学齐鲁医院血液科
出处 《中国处方药》 2013年第3期32-35,共4页 Journal of China Prescription Drug
关键词 临床应用 克拉屈滨 淋巴细胞死亡 腺苷脱氨酶 COHEN 脱氧腺苷 特异性 细胞内
分类号 R733 [医药卫生—肿瘤]
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参考文献16

  • 1Cohen A,Hirschhorn R,Horowitz SD,et al.Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency.Proc Natl Acad Sci USA,1978,75(1):472-476.
  • 2Carson DA, Wasson DB, Kaye J, et al. Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo.Proc Natl Acad Sci USA,1980,77(11):6865-6869.
  • 3Sigal DS,Miller HJ, Schram ED,et al.Beyond hairy cell: the activity of cladribine in other hematologic malignancies.Blood,2010,11616):2884 -2896.
  • 4Torrey ML, Sigal DS, Saven A.Development of cladribine at Scripps for hairy cell leukemia and current results.Leuk Lymphoma,2011,52(2):29-33.
  • 5Robak T, Jamroziak K,Gora-Tybor J,et al.Cladribine in a weekly versus daily schedule for untreated active hairy cell leukemia: final report from the Polish Adult Leukemia Group (PALG) of a pmspective,ra ndomized,multicenter trisl.Blood,2007,109(9):3672-3675.
  • 6Tallman MS,Zakarija A.Hairy cell leukemia: survival and relapse.Long-term follow-up of purine anaiog-based therapy and approach for relapsed disease. Transfus Apher Sci,2005,32(1): 99-103.
  • 7Goodman GR,Burian C,Koziol JA,et al. Extended follow-up of patients with hairy cell leukemia after treatment with cladribine.J Clin Oncol,2003,21(5): 891-896.
  • 8Seymour JF, Kurzrock R,Freireich EJ,et al.2- chlorodeoxyadenosine induces durable remissions and prolonged suppression of CD4+ lymphocyte counts in patients with hairy cell leukemia.Blood, 1994,83(10):2906- 2911.
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同被引文献47

  • 1Estey E,Dohner H. Acute myeloid leukemia[-J2. Lan- cet, 2006,368 : 1894 - 907.
  • 2Wei G,Ni W,Chiao JW,et al. A recta-analysis of CAG (cytarabine, aclarubicin, C,-CSF) regimen for the treat- ment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome[J]. J Hematol Oncol, 2011, 14:46-58.
  • 3Miyawaki S,Kawai Y,Takeshita A, et al. Phase 1 trial of FLAGM with high doses of cytosine arabinoside for relapsed, refractory acute myeloid leukemia= study of the Japan Adult I.eukemia Study Group (IALSG) [J]. Int J Hematol,2007,86:343-347.
  • 4Carella MA,Cascavilla N,Greco MM,et al. Treatment of " poor risk" acute myeloid leukemia with fludara- bine, eytarabine and G CSF (flag regimen): a single centre study T- J 1. I.euk Lymphoma, 2001, 40=295-303.
  • 5Robak T. Purine nueleoside analogues in the treatment of myeloid leukemias[J]. Leuk Lymphoma, 2003,44: 391-409.
  • 6Robak T,Wierzbowska A. Cladribine in the treatment of acute rnyeloid leukemia [J]. Leuk Res, 2014, 38: 425-427.
  • 7Robak P, Robak T. Older and new purine nueleoside analogs for patients with acute leukemias[J]. CancerTreat Rev,2013,39: 851- 861.
  • 8Robak T. Purine nucleoside analogues in the treatment of myleoid leukemias[J]. Leuk Lymphoma, 2003,44 : 391-409.
  • 9Wierzbowska A, Robak T, Pluta A, et al. Cladribine combined with high doses of arabinoside cytosine, mi- toxantrone,and G-CSF (CLAG-M) is a highly effec- tive salvage regimen in patients with refractory and re- lapsed acute myeloid leukemia of the poor risk: a final report of the Polish Adult Leukemia Group[J]. Eur J Haematol, 2008,80 : 115 - 126.
  • 10曹宁川,杨向红.肿瘤细胞对体外诱导人内皮细胞血管形成的影响及VEGF的作用[J].中国医科大学学报,2008,37(3):405-407. 被引量：6

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中国处方药
2013年 第3期

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