血必净注射液对重症急性胰腺炎患者血清TNF-α、IL-6及IL-10的影响

The effection of xuebijing injection on serum TNF-α, IL-6 and IL-10 in severe acute pancreatitis

目的观察血必净注射液对重症急性胰腺炎(SAP)患者血清白细胞介素-10(IL-10)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)的影响及其对SAP的治疗作用。方法将67例SAP患者随机分为对照组和治疗组,对照组常规给予西医治疗,治疗组在对照组基础上给予血必净注射液静脉滴注。检测治疗前及治疗8 d血清TNF-α、IL-6及IL-10水平,并评价两组治疗的临床疗效。结果治疗组临床总有效率明显高于对照组(P<0.05)。两组患者血清TNF-α及IL-6水平较治疗前均下降(P<0.01),IL-10水平较治疗前明显增高(P<0.05),与对照组比较,治疗组变化更明显(P<0.01)。结论血必净注射液能抑制SAP患者TNF-α分泌,下调IL-6水平,上调IL-10水平,对SAP具有良好的治疗作用。

Objective To observe the effection of Xuebijing Injection on serum tumor necrosis factor-α （TNF-α）, in- terleukin-6 （IL-6）, interleukin- 10 （ IL- 10） in Severe acute pancreatitis （SAP） and its effect on the treatment of SAP. Methods Sixty-seven patients with SAP were randomly divided into the treatment group and control group. The con- trol group was only treated with conventional western medicine and the treatment group was treated with both western medicine and xuebljing injection. Tested the serum levels of TNF-α, IL-6, and IL-10 before and after treatment 8 days separately. Evaluated the clinical efficiency of the treatment of two groups. Results The overall response impact of treatment group was significantly higher than that of control group （P 〈 0.05）. Compared with the serum levels of TNF-α, IL-6 before the treatment, the serum levels of both TNF-α and IL-6 after the treatment decreased signifi- cantly （P 〈 0.01 ） and the IL-10 levels increased obviously （P 〈 0.05）. Compared with the control group, the change of the treatment group was significant （P 〈 0.01 ）. Conclusion Xuebijing Injection could inhibit the TNF-α secretion, reduce the IL-6 levels, up-regulation IL-10 levels, and have s a good therapeutic effect on the severe acute pancre- atitis （SAP）.