左卡尼汀治疗老年慢性心力衰竭患者的疗效观察

Curative effect observation of levocarnitine in gerontal patient with chronic cardiac failure

目的探讨左卡尼汀在老年慢性心力衰竭患者中的临床效果。方法将90例老年慢性心力衰竭患者随机分为观察组与对照组,每组45例,所有患者采用常规抗心衰治疗4周,观察组另给予左卡尼汀治疗,对比两组患者心功能指标及临床疗效。结果治疗前两组患者SV、CO、CI、LVEF、VE/VA无显著差异(P>0.05),治疗后两组患者SV、CO、CI、LVEF、VE/VA高于治疗前(P<0.05),治疗后观察组SV、CO、CI、LVEF、VE/VA高于对照组(P<0.05)。观察组临床有效率为97.8%,对照组临床有效率为86.7%,观察组临床有效率高于对照组。结论左卡尼汀在老年慢性心功能不全的治疗中可有效改善心肌细胞能量代谢状态,增强心肌收缩功能,改善心功能。

Objective To investigate the clinical curative effect of levocarnitine in gerontal patient with chronic car- diac failure （CHF）. Methods A total of 90 cases of gerontal patients with CHF were selected and randomized into control group and observation group ,there was 45 cases in every groups ,all patients taken conventional therapy with resisting congestive heart failure in 4 weeks,patients in observation taken levocarnitine in additions,index of heart function were contrasted between control group and observation group, and clinical curative effect were contrasted be- tween control group and observation group. Results Before therapy,SV ,CO,CI,LVEF and VE/VA was identical be- tween control group, and observation group; in all patients, SV, CO,CI,LVEF and VE/VA was higher after therapy than before therapy; after therapy,SV,CO,CI,LVEF and VE/VA was higher in observation group than in control group. Clinical curative effect was 97.8% in observation group and was 86.7% in control group, clinical curative effect was higher in observation group than in control group. Conclusion Levocarnitine can improve energy metabolism of myocardium in Gerontal patient with CHF, to reinforce myocardial contractile force, improve heart function.