宫颈冷刀锥切术对早期宫颈癌患者生育能力和妊娠结局的影响

Influence of fertility and pregnancy outcome in early cervical cancer patients after cold knife conization

目的探究并分析宫颈冷刀锥切术对早期宫颈癌患者生育能力和妊娠结局的影响。方法选择浙江省金华市中心医院2008年12月～2009年12月妇产科收治的宫颈冷刀锥切术治疗的65例早期宫颈癌患者为观察组，选择同期孕前门诊的65例无宫颈锥切术史的妇女为对照组。采用t检验和χ2检验比较两组女性生育能力、妊娠结局及围生儿情况。结果观察组患者不孕发生率、剖宫产率、早产、新生儿窒息、胎膜早破和新生儿低体重发生率明显高于对照组，差异有统计学意义（P〈0．05）。结论宫颈冷刀锥切术后宫颈原位癌或早期宫颈浸润癌患者妊娠情况较正常人群差，早产、新生儿窒息、胎膜早破和新生儿低体重发生率明显增加，而且还影响患者选择正确的分娩方式。

Objective To investigate the influence of fertility and pregnancy outcome in early cervical cancer patients after cold knife conization. Methods Sixty-five early cervical cancer patients after cold knife eonization who were treated in the department of obstetrics and gynecology of the central hospital in Jinhua city of Zhejiang province from December 2008 to December 2009 were the observation group, sixty-five women without cold knife conization were the control group. Fertility, pregnancy outcome and perinatal situation of two groups were evaluated by using t test and χ2 test. Results Incidence of infertility, the cesarean section rate, preterm birth, neonatal asphyxia, premature rupture of membranes and incidence of low birth weight newborn were higher in the observation group than that in the control group （P 〈 0.05）. Conclusion Pregnancies in early cervical cancer patients after cold knife conization is worse than wom- en without cold knife conization,it not only can markedly increase preterm birth, neonatal asphyxia, premature rupture of membranes and incidence of low birth weight newborn,but also affect patients choosing the right way of delivery.