Pd_2dba_3高效催化碘代芳烃的双羰化反应合成α-酮酰胺

Pd_2dba_3:A Highly Active Catalyst of Double Carbonylation Reaction for Synthesis of α-keto amide

以高效、廉价易得的Pd2dba3作为催化剂,成功实现了碘代芳烃的双羰化反应,得到的α-酮酰胺最高分离收率达90%.该催化体系对于不同取代基的碘代芳烃和仲胺都具有广泛的底物适应性.

An efficient double carbonylation reaction of aryl iodids were carried out in presence of a catalytic system in situ prepared from Pd2dba3,achieving the corresponding products α-keto amide with up to 90% of yield under mild conditions.This developed catalytic system demonstrates a broad tolerance of aryl iodides with various substituents during the double carbonylation reaction.