先天性室间隔缺损介入治疗术后近期疗效及影响预后的危险因素分析

Short-term efficacy of percutaneous interventional therapy on congenital ventricular septal defect and the risk factors for the prognosis

目的:分析先天性室间隔缺损(VSD)患者介入治疗术后近期疗效及影响预后的危险因素。方法:收集我院2003年10月至2012年10月先天性VSD接受介入治疗患者的临床资料,分析其疗效,并采用多因素Logistic回归分析筛选影响近期预后的危险因素。结果:共搜集482例患者的临床资料,所有患者随访1个月,共死亡1例,病死率为0.21%;多因素Logistic回归分析显示:年龄(3～5岁)、体重(10～20kg)、手术时间(>120min)及合并其他心血管畸形是先天性VSD患者介入治疗术后近期主要不良事件的独立危险因素。结论:先天性VSD患者介入治疗疗效肯定;影响先天性VSD患者经导管介入治疗术后预后的独立危险因素为年龄、体重、手术时间及合并心血管畸形。因此,为改善先天性VSD患者介入治疗预后,对年龄小、体重轻、手术时间长及合并心血管畸形的患者需谨慎。

Objective To analyze the short-term efficacy of percutaneous interventional therapy on congenital ventrieular septal defect （VSD） and the risk factors for the prognosis. Methods The clinical data of 482 patients with congenital VSD, who receive percutaneous interventional therapy, were collected, and the short-term efficacy and risk factors for the prognosis were analyzed by lnuhivariate Logistic regression analysis. Results With 1-month of follow-up, 1 of 482 patients died, the mortality was 0.21%. Multivariate Logistic regression analysis showed that age （3 - 5 years）, weight （10 - 20 kg）, time of operation （〉 120 min） and combined cardiovascular malformations were the independent risk factors for the prognosis of patients with congenital VSD, who received percutaneous interventional therapy. Conclusions It is positive for the efficacy of transcatheter intervention treatment on patients with congenital VSD, and the independent risk factors for the prognosis were age, weight, duration of procedure, and combined cardiovascular malformations.