斯替宁碱的合成方法研究进展

Research Progress on the Synthesis of Stenine

具有1H-吡咯并[1,2-a]氮杂和多取代全氢吲哚结构的斯替宁碱是百部生物碱的代表性结构,其多环结构和连续的七个手性中心对不对称合成化学极具挑战性.按斯替宁碱合成中使用的关键方法分类,对斯替宁碱的合成研究进展进行了综述.

The alkaloid stenine which has a representative pyrrolo[1,2-a]azepine nucleus and a highly substituted perhydro- indole ring system is unique among Stemona alkaloids. The polycyclic system and the seven contiguous stereogenic centers in （--）-stenine present a challenge for asymmetric organic synthesis. Progresses toward the synthesis of stenine are reviewed in terms of the key strategies employed.