摘要
淫羊藿素是淫羊藿苷的苷元,具有抗骨质疏松和调节雌激素等多种生物活性.以间苯三酚为原料,经Houben-Hoesch反应、一锅法Algar-Flynn-Oyamada反应和铕促异戊烯基重排等8步反应实现了淫羊藿素的合成,总收率4.2%.中间体及最终产物的结构均通过NMR和HRMS进行了表征.
Icaritin, the aglycone of icariin, has many pharmacological and biological activities, such as antiosteoporosis activ- ity and estrogen regulation. The synthesis of caritin via an eight-step strategy including Houben-Hoesch acylation, one-pot Algar-Flynn-Oyamada reaction and europium-promoted prenylation etc., from anhydrous phloroglucin is reported in this pa- per. All the compounds were characterized by NMR and HRMS spectea.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2013年第6期1298-1303,共6页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.20932007)资助项目~~
