小青龙汤对慢性阻塞性肺疾病急性发作期患者细胞因子及肺功能的影响

Effect of Xiao Qinglong Decoction on Cytokines and Lung Function in Chronic Obstructive Pulmonary Disease Patients at Acute Exacerbation Stage

目的:观察小青龙汤对慢性阻塞性肺疾病急性发作期(AECOPD)细胞因子及肺功能的影响,并探讨其作用机理。方法:将92例AECOPD患者随机分为2组,各46例,对照组按照AECOPD治疗指南给予西药常规治疗,治疗组在对照组基础上加用小青龙汤口服,比较2组治疗前、治疗14天后血清C-反应蛋白(CRP)、白细胞介素-8(IL-8)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)变化及肺功能指标肺活量(FVC)、第1秒用力呼气容积(FEV)1、第1秒用力呼气容积占用力肺活量百分比(FEV1/FVC)的变化。结果:治疗组治疗后CRP、IL-8、IL-6、TNF-α水平均较治疗前改善(P<0.05),2组治疗后CRP、IL-8、IL-6、TNF-α水平比较,差异均有显著性意义(P<0.05),观察组较对照组改善更明显。治疗组治疗后FVC、FEV1、FEV1/FVC(%)均改善(P<0.05);2组治疗后FVC、FEV1、FEV1/FVC比较,差异均有显著性意义(P<0.05),治疗组较对照组改善更显著。结论:小青龙汤联合西药治疗AECOPD疗效优于单纯西药治疗,其作用机理可能是通过降低AE-COPD患者相关细胞因子,从而改善肺功能。

Objective： To observe the effect of Xiao Qinglong Decoction in the treatment of acute exacerbation of chronic obstructive pulmonary disease（AECOPD）, and to explore its therapeutic mechanism. Methods： Ninety-two AECOPD patients were equally randomized into 2 groups. Both control group and treatment group were given conventional western medicine, and the treatment group was given oral use of Xiao Qinglong Decoction additionally.Before treatment and after treatment for 14 days, the serum C-reactive protein（CRP）, intedeukin-8（IL-8）, interleukin-6（IL-6）, tumor necrosis factor（TNF- α） levels as well as the lung function indexes of forced vital capacity（FVC）, forced expiratory volume in one second （FEV1）, and FEV1/FVC were examined in both groups. Results： After treatment, CRP, IL-8, IL-6, TNF-α were significantly improved in both groups（P〈 0.05 compared with those before treatment）, and the improvement was obvious in the treatment group（P 〈 0.05）. Pulmonary function indices were also improved in both groups, and the improvement in the treatment group was superior to that in the control group（P 〈 0.05）. Conclusion： Xiao Qinglong Decoction plus western medicine has better effect than western medicine alone in the treatment of AECOPD, and its mechanism may be related with the improvement of lung function through the reduction of cytokines in AECOPD patients.