立项前后我院围术期预防用抗菌药物情况调查分析

Investigation and Analysis of Perioperative Prophylactic Application of Antibiotics in Our Hospital before and after Project Proposal

目的:了解我院围术期患者预防用抗菌药物情况,促进临床合理用药。方法:采用回顾性方法,随机抽取我院2009年1月至2010年5月(立项前)611例(每月约36份)和2011年1-12月(立项后)361例(每月约30份)手术患者病历,结合药敏试验结果及抗菌药物使用频度(DDDs),对平均每例患者使用抗菌药物费用、不合理用药造成患者多出费用等情况进行比较分析。结果:立项后与立项前比较,平均每例患者使用抗菌药物费用明显减少([240.72±63.20)元vs(.383.20±76.60)元)];不合理用药造成患者多出费用显著减少([29.71±8.50)元vs(.87.87±26.12)元];围术期预防用抗菌药物的合理率显著提高(70.08%vs.2.13%)。结论:通过对我院立项后与立项前围术期预防用抗菌药物存在的问题实施有针对性的干预,患者多出费用显著减少,减轻了患者的经济负担,同时提高了医院围术期预防用抗菌药物的合理率。

OBJECTIVE： To investigate the perioperative prophylactic application of antibiotics in our hospital, and to promote rational drug use in the clinic. METHODS： By retrospective study, medical records of 611 cases were randomly selected in our hospital from Jan. 2009 to May 2010 （before project proposal, approximately 36 copies per month）, and 361 cases were randomly selected from Jan. to Dec. in 2011 （after project proposal, approximately 30 copies per month）. Based on results of drug sensitivity test and DDDs of antibiotics, antibiotics cost per capita, additional cost caused by irrational drug use and so on were analyzed comparatively. RESULTS： After project proposal, antibiotics costs decreased significantly [（240.72±63.20） yuan vs. （383.20±76.60） yuan]; additional cost caused by irrational use of drugs decreased significantly [（29.71±8.50） yuan vs. （87.87±26.12） yuan]; the rationality of perioperative prophylactic application of antibiotics increased significantly （70.08% vs. 2.13%）. CONCLUSIONS： Targeted intervention measures are adopted to resolve the existing problems about perioperative prophylactic application of antibiotics before and after project proposal, and additional cost is reduced significantly and the economic burden of patients is lightened. The rationality of perioperative prophylactic application of antibiotics has been improved in our hospital.