我院353例药品不良反应报告分析

Analysis of 353 Cases of Adverse Drug Reaction Reports in Our Hospital

目的:探讨我院药品不良反应(ADR)发生的特点及规律,为临床合理用药及药品安全性评价提供参考。方法:对我院2011-2012年收集到的353例有效ADR报告进行统计、分析。结果:353例ADR报告中,涉及药品232种,≥60岁患者发生ADR的比例最高(120例,占33.99%);静脉注射给药引发的ADR最多(281例,占79.60%);最易引发ADR的药物为抗感染药(111例,占31.44%),其次为中药注射剂(86例,占24.36%);ADR损害类型主要以皮肤及其附件损害为主(215例,占60.91%),其次为消化系统和心血管系统损害;新的、严重的ADR30例。结论:临床应重视和加强ADR监测,合理用药,减少或避免ADR的发生。

OBJECTIVE： To explore the characteristics and regularity of adverse drug reactions （ADRs）in our hospital in order to provide reference for rational use of drugs and drug safety evaluation. METHODS： 353 cases of ADRs reports collected in our hospital from 2011 to 2012 were analyzed statistically. RESULTS： Of total 353 ADR cases, 232 kinds of drugs were involved, ADRs occurring in patients over the age of 60 was the highest （120 cases, accounting for 33.99% ） ;the largest number of ADRs were caused by intravenous injection （281 cases, accounting for 79.60% ） ; ADRs were most likely caused by anti-infective drugs （111 cases, accounting for 31.44% ）, followed by TCM preparation（86 cases, accounting for 24.36% ）;the main types of ADRs were damage to the skin and its appendents（215 cases, accounting for 60.91% ）, followed by the damage of digestive system and cardiovascular system; there were 30 new or severe ADRs. CONCLUSIONS：We should pay attention to and strengthen ADR moni-toring and rational use of drugs in order to reduce or avoid the occurrence of ADRs.