方剂归经量化研究方法初探

Quantitative analysis method of meridian entry of TCM formulas

目的研究方剂的归经效用,建立方剂归经量化数学模型,探索一种方剂归经定量研究的方法。方法以药物归经学说为理论依据,结合方剂的组方配伍规律,应用层次分析法(AHP)及向量理论,构建方剂"归经强度"数学模型。结果利用计算机自动化处理,对"逍遥散"等传统方剂进行归经分析,这种方法较准确地量化描述方剂的归经强度。结论方剂归经强度模型实现了方剂"归经强度"的差异性量化分析,阐释了方剂的组方配伍规律,可为系统研究方剂归经与病症对应规律提供一定的科学依据。

Objective To study the meridian entry effectiveness of formulas, establish a mathematical model and establish a method for quantitative analysis of formula meridian entry. Methods A mathematical model of intensity of formula meridian entry was established based on the theory of medicinal meridian entry, laws of formula designing and construction, analytic hierarchy process （AHP） and vector theory. Results By computer automatic processing, the traditional formulas like Xiaoyao San were given analysis of meridian entry. The method described quantitatively and accurately the intensity of formula meridian entry. Conclusion The model has achieved quantitative analysis on difference in the intensity of formula meridian entry, explained the laws of formula designing and construction, and provided some scientific evidence for systemic research on formula meridian entry and rules of meridiandisease correspondence.