摘要
AIM:To study the chemical constituents and their anti-amnesic effect from the hooks of Uncaria rhynchophylla.METHODS:The isolation of compounds was performed by chromatographic techniques and their structures were identified on the basis of spectral analysis.Their ameliorating effects on scopolamine-induced memory impairment in vivo using a Morris water-maze task and passive avoidance task system were evaluated.RESULTS:Activity-guided fractionation of the total extracts resulted in the isolation of four constituents,trans-anethole(1),p-anisaldehyde(2),estragole(3),and 3-oxo-olean-12-en-28-oic acid(4),which were found for the first time from this plant.CONCLUSION:Compound 1 exhibited a better memory enhancing effect than tacrine,a positive agent,at the same dose in the passive avoidance test and a similar property in the water-maze test,and its action may be mediated,in part,by the acetylcholine enhancing cholinergic nervous system.
AIM：To study the chemical constituents and their anti-amnesic effect from the hooks of Uncaria rhynchophylla.METHODS：The isolation of compounds was performed by chromatographic techniques and their structures were identified on the basis of spectral analysis.Their ameliorating effects on scopolamine-induced memory impairment in vivo using a Morris water-maze task and passive avoidance task system were evaluated.RESULTS：Activity-guided fractionation of the total extracts resulted in the isolation of four constituents,trans-anethole（1）,p-anisaldehyde（2）,estragole（3）,and 3-oxo-olean-12-en-28-oic acid（4）,which were found for the first time from this plant.CONCLUSION：Compound 1 exhibited a better memory enhancing effect than tacrine,a positive agent,at the same dose in the passive avoidance test and a similar property in the water-maze test,and its action may be mediated,in part,by the acetylcholine enhancing cholinergic nervous system.
出处
《中国天然药物》
SCIE
CAS
CSCD
2013年第4期391-395,共5页
关键词
实验药理学
药理
病理作用
天然药物
Uncaria rhynchophylla Trans-anethole Passive avoidance task Water-maze task
